Bicalutamide Pharmacology


About Bicalutamide
Non steroidal anti estrogen, anti neoplastic.
Mechanism of Action of Bicalutamide
This antiandrogenic drug binds to the receptor of androgens on the cells of prostate gland. Thus it blocks the action of androgen on prostate gland and prevents growth of androgen stimulated prostate cancer.
Pharmacokinets of Bicalutamide
Absorption- Well absorbed after oral administration
Distribution-Widely distributed in the body.96% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites. S isomer of the drug is metabolized by glucoronidation and R-isomer is metabolized by glucoronidation followed by oxidation to its metabolites
Excretion- Excreted via urine and feces
Onset of Action for Bicalutamide
Duration of Action for Bicalutamide
Half Life of Bicalutamide
5.9 days
Side Effects of Bicalutamide
1. Dizziness
2. Hot flushes
3. Paresthesia
5. hypertension
6. Peripheral edema
7. Diarrhea
8. Constipation
9. Nausea
10. Vomiting
11. Nocturia
12. Hematurea
13. Gynecomastia
14. Urinary tract infection
15. Anemia
16. Flu-like syndrome
17. Infection
18. Dyspnoea
19. Back pain
20. Pelvic pain
21.Bone pain
Contra-indications of Bicalutamide
Contraindicated in patients with hypersensitivity to the drug or its components
Special Precautions while taking Bicalutamide
Use with caution in patients with
1. Hepatic impairment
2. Recent vaccinations
3. Anticoagulant therapy
Pregnancy Related Information
Old Age Related Information
Use with Caution
Breast Feeding Related Information
Children Related Information
Indications for Bicalutamide
Prostate cancer (metastatic)
Interactions for Bicalutamide
Typical Dosage for Bicalutamide
50 mg daily
Schedule of Bicalutamide
Storage Requirements for Bicalutamide
Stored at room temperature away from heat and moisture. Keep out of reach of children
Effects of Missed Dosage of Bicalutamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bicalutamide
Give symptomatic and supportive treatment. Induce emesis if patient is alert.

Home Delivery for Bicalutamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bicalutamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bicalutamide and other medicines and health products. Home delivery services for bicalutamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take bicalutamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bicalutamide before they complete the sale. You can get this information while placing the order for bicalutamide with the pharmacy.

Bicalutamide is a generic medicine name and there are several brands available for it. Some of the brands for bicalutamide might be better known than bicalutamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bicalutamide in stock, you can ask for one of the branded alternatives for bicalutamide.