Goserelin Pharmacology

Goserelin

About Goserelin
GnRH agonist, a potent synthetic decapeptide analogue, Antineoplastic Agent.
Mechanism of Action of Goserelin
Goserelin is a synthetic Gonadotropin Releasing hormone analog. It acts as a potent inhibitor of pituitary gonadotropin secretion. Proliferations of Prostatic cells are stimulated by Dihydrotestosterone generated from circulating Testosterone hence it is directly under the control of LH-RH/FSH-RH. Initially treatment with this drug causes an acceleration of the growth of prostatic tumors and later causes a decline in tumor growth rate as a result of down regulation of LH-RH/FSH-RH receptors in the anterior hypophysis and androgen receptors in tumor cells.
Pharmacokinets of Goserelin
Absorption: It is rapidly absorbed after subcutaneous absorption. Distribution: It is widely distributed in the body. Metabolism: It undergoes hepatic metabolism. Excretion: It is excreted mainly in the urine.
Onset of Action for Goserelin
N/A
Duration of Action for Goserelin
N/A
Half Life of Goserelin
3- 5 hours
Side Effects of Goserelin
1.Dizziness
2.Drowsiness
3.Menstrual bleeding
4.Renal insufficiency
5.Insomnia
6.Asthenia
7.Headache
8.Peripheral edema
9.Nausea
10.Vomiting
11.Impotence
12.Urinary obstructions
13.Vaginitis
14.Rash
15.Diaphoresis
16.Acne
17.Sweating
18.Hirsutism
19.Hot flushes
20.Anorexia
21.Vaginal dryness
Contra-indications of Goserelin
1.Hypersensitivity to Goserelin, LH-RH and LH-RH analogues
Special Precautions while taking Goserelin
1.Osteoporosis
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Goserelin
1.Prostatic carcinoma
2.Breast cancer
3.Endmetriosis
Interactions for Goserelin
N/A
Typical Dosage for Goserelin
Adult:
Subcutaneous(Implant): 3.6mg implant S.C.every 28days into the upper abdominal wall for 6 months
Schedule of Goserelin
N/A
Storage Requirements for Goserelin
Store the drug at room temperature below 25 degree Celsius.Do not freeze.
Effects of Missed Dosage of Goserelin
Take the missed dose as soon as noticed.
Effects of Overdose of Goserelin
Give supportive measures and symptomatic treatment.

Home Delivery for Goserelin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including goserelin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for goserelin and other medicines and health products. Home delivery services for goserelin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take goserelin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for goserelin before they complete the sale. You can get this information while placing the order for goserelin with the pharmacy.

Goserelin is a generic medicine name and there are several brands available for it. Some of the brands for goserelin might be better known than goserelin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have goserelin in stock, you can ask for one of the branded alternatives for goserelin.