Thiopentone Pharmacology


About Thiopentone
An ultra-short-acting barbiturate(thiobarbiturate), Intravenous General anesthetic.
Mechanism of Action of Thiopentone
Thiopentone mainly acts on Picrotoxin site of GABA -BZD receptor chloride ion channel complex. It prolongs the duration of GABA induced chloride channel opening and produces hyperpolarisation and decreases firing rate of neurons. Thiopentone also has GABA mimetic action. Thiopentone will decreases presynaptic and postsynaptic excitation. Thiopentone depresses polysynaptic midbrain reticular activating system and produces anaesthesia.
Pharmacokinets of Thiopentone
Absorption: It is well absorbed after intravenous administration.
Distribution: It is initially distributed to highly vascular tissues in the body in protein bound form and then redistributed to fatty tissues.
Metabolism: It is extensively but slowly metabolised in the liver.
Excretion: Only a very small amount of the drug is excreted through urine.
Onset of Action for Thiopentone
Within 1 minute
Duration of Action for Thiopentone
10 minutes
Half Life of Thiopentone
1 hour
Side Effects of Thiopentone
1. Apnoea
2. Shivering
3. Delirium
4. Allergic reactions
5. Thrombophlebitis
6. Respiratory depression
7. Cardiac arrhythmia
8. Laryngospasm
9. Bronchospasm
Contra-indications of Thiopentone
1. Hypersensitivity to Thiopentone and other barbiturates
2. Acute intermittent Porphyria
3. Hypotension
4. Asthma
5. Patient hypersensitive to General anesthetics
Special Precautions while taking Thiopentone
1. Status asthmatics
2. Renal impairment
3. Liver diseases
4. Cardiovascular diseases
5. Hypovolaemia
6. Shock
7. Severe Anaemia
8. Myxedema
9. Addison`s disease
10. Myasthenia gravis
11. Increased intracranial pressure
12. Severe haemorrhage
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Thiopentone
1. Anaesthesia
2. Rapid control of convulsions
Interactions for Thiopentone
Narcotics: Those of phenobarbitone required to induce anaesthesia reduced.
Phenothiazines: Increased frequency and severity of neuromuscular excitation and hypotension.
Typical Dosage for Thiopentone
Adult: Dosage should be individualised.
General anaesthesia: 3 - 5 mg / kg as 2.5 % solution
Control of convulsion: 50 - 125 mg as 2.5 % solution

Schedule of Thiopentone
Storage Requirements for Thiopentone
Store the dry form of powder at room temperature. The reconstituted solution is stable for 3 days at room temperature and for 1week if refrigerated
Effects of Missed Dosage of Thiopentone
Take the missed dose as soon s noticed and if it is the time to take the next dose then skip the missed dose.Do not double the dose.
Effects of Overdose of Thiopentone
Give supportive measures and symptomatic treatment. To treat hypotension IV fluids or vasopressors should be given.

Home Delivery for Thiopentone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including thiopentone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for thiopentone and other medicines and health products. Home delivery services for thiopentone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take thiopentone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for thiopentone before they complete the sale. You can get this information while placing the order for thiopentone with the pharmacy.

Thiopentone is a generic medicine name and there are several brands available for it. Some of the brands for thiopentone might be better known than thiopentone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have thiopentone in stock, you can ask for one of the branded alternatives for thiopentone.