The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
10.Inhibition of growth in children
20.Delayed wound healing
27.Posterior sub capsular cataract
29.Sodium and fluid retention
31.Increased intracranial pressure
5.Systemic fungal infections
8.Not to be given intravenously
2.Monitor vital parameters, therapeutic response and adjust the dosage
3.Use lower dosages as much as possible
6.Primary psychosis and psychoneurosis
7.Recent myocardial infarction
17.Non specific Ulcerative colitis
19.Recent intestinal anastomosis
Oral contraceptives: May increase half life and concentration of triamcinolone.
Oestrogens: May decrease clearance of triamcinolone.
Rifampicin: Decreases efficacy.
Triamcinolone effects the action of the following:
Anticiholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increased cyclosporine efficacy, toxicity may be enhanced.
Digitalis glycosides: Increased possibility of toxicity associated with hypokalaemia.
Isoniazid: Decreased serum levels of isoniazid.
Salicylates: Decreased serum levels of salicylates.
Diuretics: May cause increased hypokalaemia and increased hyperglycemia.
Non-depolarising muscle relaxants: Altered response.
Theophyllines: Altered response of either agent.
Lab Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I uptake. Decreases T3 serum levels. Decreases serum potassium.
Children: 4 to 12mg/day
Adrenal insufficiency: 4 to 12mg/day as once daily or as divided doses depending up on the severity of the condition.
Children: 117mcg/kg/day as once daily or as divided doses.
Collagen diseases, Tuberculous meningitis: 30 to 48mg/day.
Respiratory diseases: 16 to 48mg/day as once daily or as divided doses depending up on the severity of the condition.
Malignancies: 16 to 100mg/day as once daily or as divided doses depending up on the severity of the condition.
Parenteral: 4 to 32mg/day as once daily or as divided doses
I.M.: 40 to 60mg as deep I.M. injection depending up on the severity of the condition.
In asthma and hey fever increases the dosage up to 100mg as required by the patient.
Intra-articular: 2.5mg to 15mg depending up on the severity of the condition.
Intradermal: 0.2 to 0.3ml
Home Delivery for Triamcinolone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including triamcinolone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for triamcinolone and other medicines and health products. Home delivery services for triamcinolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take triamcinolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for triamcinolone before they complete the sale. You can get this information while placing the order for triamcinolone with the pharmacy.
Triamcinolone is a generic medicine name and there are several brands available for it. Some of the brands for triamcinolone might be better known than triamcinolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have triamcinolone in stock, you can ask for one of the branded alternatives for triamcinolone.