Midazolam Pharmacology
Midazolam
Midazolam is used as adjuncts in anaesthesia for anxiolysis, amnesia and sedation prior to induction of anaesthesia
2.Drowsiness
3.Light headedness
4.Slurred speech
5.Nausea
6.Constipation or diarrhoea
7.Tremor
8.Dependence
9.Anorexia
10.Confusion
11.Light headedness
12.Mood changes
13.Muscle rigidity
14.Amnesia
15.Hiccups
2.Acute angle closure glaucoma
3.Patients in shock
4.Comatose
5.Acute alcohol intoxication
2.Hepatic impairment
3.Use caution while driving vehicles or operating machines or people involving any other dangerous activities
NEONATES contraindicated
2.In general anaesthesia
3.Sedative prior to endoscopic and diagnostic procedure
Azole antifungal agents: Enhanced CNS depession and prolonged effects.
CNS depressants: May increase risk of hypoventilation and contribute to prolonged effect.
Ethanol: Increased CNS effects with acute ethanol ingestion.
Oral contraceptives: May result in prolongation of midazolam half life.
Rifamycin: Increase in midazolam & metabolite clearance & decrease in elimination half life.
Theophylline: Sedative effect of midazolam may be antagonised.
Thiopental: A reduction in induction dosage requirement of thiopental.
Verapamil: May produce increased CNS depression and prolonged effects.
Sedative (IM injection): 0.7 - 0.8 mg / kg body weight; 30 - 60 minutes before surgery
Conscious sedation: 1-2 mg is given as slow IV injection. The dose can be increased by 0.5 - 1 mg every 2 minutes until the desired effect is produced. Total dose up to 7.5 mg may be used.
In general anaesthesia as an inducer:
A. Unpremedicated: 300 - 350 mcg / kg body weight (as slow IV injection for 30 seconds). The dose can be increased by 25 % of the initial dose to produce the desired effect.
B. Premedicated: 250 mcg / kg body weight (as slow IV injection for 30 seconds).
Continuous sedation for patients in intensive care unit: 10 - 50 mcg / kg body weight as IV infusion. Maintenance dose: 20 - 100 mcg / kg / hour. The dose can be increased or decreased by 25 - 50 % of the initial dose to produce the desired effect.
Children:
Continuous sedation for patients in intensive care unit: 50 - 200 mcg / kg body weight as IV infusion. Maintenance dose: 60 - 120 mcg / kg / hour. The dose can be increased or decreased by 25 - 50 % of the initial dose to produce the desired effect.
Sedative for short procedure (IM): 0.1 - 0.15 mg / kg. The dose can be increased up to 0.5 mg / kg
Home Delivery for Midazolam in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including midazolam.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for midazolam and other medicines and health products. Home delivery services for midazolam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take midazolam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for midazolam before they complete the sale. You can get this information while placing the order for midazolam with the pharmacy.
Midazolam is a generic medicine name and there are several brands available for it. Some of the brands for midazolam might be better known than midazolam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have midazolam in stock, you can ask for one of the branded alternatives for midazolam.
