Prilocaine Pharmacology


About Prilocaine
Amino amide derivative, Local Anesthetic.
Mechanism of Action of Prilocaine
Prilocaine is an amide type local anaesthetic. It exerts its action by interacting with a receptor situated within the voltage sensitive Na+ channels and raises the threshold of channel opening. It blocks nerve conductions by decreasing the entry of sodium ions during upstroke of action potential. The rate of rise of action potential and maximum depolarization decreases in a concentration dependent manner and causing slowing of conduction and finally local depolarization fails to reach the threshold potential and conduction block ensures. Na+ permeability fails to increase in response to an impulse or stimulus. Thus the drug exerts its local anesthetic action by membrane stabilizing effect.
Surface anaesthesia: Cream containing Lidocaine 2.5% and Prilocaine 2.5% as a eutectic mixture produce local anaesthesia when applied topically to intact skin. It is useful in venepuncture, extracorporeal shock, retrobulbar injections, lumbar puncture, genital wart removal, laser treatment, intravenous or arterial cannulation, split skin grafting, and circumcision.

Pharmacokinets of Prilocaine
Absorption: It is completely absorbed after parenteral administration. Distribution: About 55% of the drug is distributed in protein bound form. Metabolism: It undergoes metabolism in the liver and also in the kidney. Excretion: Drug and its metabolites are excreted mainly in urine
Onset of Action for Prilocaine
1 - 2 minute
Duration of Action for Prilocaine
Half Life of Prilocaine
Side Effects of Prilocaine
1. Drowsiness
2. Paresthesia
3. Blurred vision
4. Nausea
5. Nystagmus
6. Disorientation
7. Twitching
8. Fits
9. Hypotension
10. Cardiac depression
11. Bradycardia
12. Asystole
13. Ventricular fibrillation
14. Cardiac arrest
15. Respiratory arrest
1.Transient paleness

Contra-indications of Prilocaine
1. Hypersensitivity to the drug
2. AV block
3. SA block
4. Intra ventricular block
5. Cardiac decompensation
6. Supra ventricular arrhythmia
7. Conduction disturbances
8. Strokes Adams Syndrome
9. Wolff Parkinson White syndrome
10. Infection or inflammation in puncture region
11. Septicemia
12. Severe hypertension
13. Spinal deformities
14. Neurological disorders
15. Anaemia
16. Methaemoglobinaemia
Special Precautions while taking Prilocaine
1. Hepatic impairment
2. Renal impairment
3. Deliberate individuals
4. Complete or second degree heart block
5. Sinus Bradycardia
6. Heart failure
7. Hypotension
8. Shock
9. Malignant hyperthermia
10. Monitor ECG with caution during therapy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Prilocaine
1.Nerve block
2.Infiltration anaesthesia
Interactions for Prilocaine
Typical Dosage for Prilocaine
Dental infiltration: 40 to 80 mg (1 to 2 ml) as a 4% solution;
Children (above 6 month of age):5 mg / kg body weight
Adult: Apply the cream under an occlusive dressing for 60 minutes
Removal of genital warts: Apply for 5 - 10 minutes without occlusive dressing
Children: Apply the cream under an occlusive dressing for 30 minutes

Schedule of Prilocaine
Storage Requirements for Prilocaine
Store below 25degree C. Keep out of reach of children.
Effects of Missed Dosage of Prilocaine
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Prilocaine
Give supportive measures and symptomatic treatment.

Home Delivery for Prilocaine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including prilocaine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for prilocaine and other medicines and health products. Home delivery services for prilocaine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take prilocaine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for prilocaine before they complete the sale. You can get this information while placing the order for prilocaine with the pharmacy.

Prilocaine is a generic medicine name and there are several brands available for it. Some of the brands for prilocaine might be better known than prilocaine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have prilocaine in stock, you can ask for one of the branded alternatives for prilocaine.