Distribution- 75 to 99% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by demethylation and hydroxylation.
Excretion- Excreted via bile.
2. Liver problems
3. Kidney problems
8. Diabetes mellitus
13. Loss of appetite
19. Herpes zoster infections
20. Polyoma viral infections
2. Kidney disease
Avoid concomitant use of potassium-sparing diuretics. Concomitant use of drugs which inhibit the cytochrome P450 (CYP3A) potentiate the effects of tacrolimus.
Kidney transplantation- 0.2mg/kg/day in adults as two divided doses.
Liver transplantation- 0.10-0.15mg/kg/day in two divided doses.
Maintenance dosage should be individualized so as to maintain whole blood concentration between 5-20 ng/ml.
Children- Generally need doses 1.5 to 2 times greater than those in adults.
Home Delivery for Tacrolimus in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tacrolimus.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tacrolimus and other medicines and health products. Home delivery services for tacrolimus may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take tacrolimus only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tacrolimus before they complete the sale. You can get this information while placing the order for tacrolimus with the pharmacy.
Tacrolimus is a generic medicine name and there are several brands available for it. Some of the brands for tacrolimus might be better known than tacrolimus itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tacrolimus in stock, you can ask for one of the branded alternatives for tacrolimus.