- Medicine India
- Generic Medicines
- Pharmacology For Domperidone + Paracetamol
Domperidone + Paracetamol Pharmacology
Domperidone + ParacetamolAbout Domperidone + ParacetamolN/AMechanism of Action of Domperidone + ParacetamolN/APharmacokinets of Domperidone + ParacetamolN/AOnset of Action for Domperidone + ParacetamolN/ADuration of Action for Domperidone + ParacetamolN/AHalf Life of Domperidone + ParacetamolN/ASide Effects of Domperidone + ParacetamolN/AContra-indications of Domperidone + ParacetamolN/ASpecial Precautions while taking Domperidone + ParacetamolN/APregnancy Related InformationContraindicated; since Domperidone is contraindicated in pregnancy, the combination generic cannot be used in pregnant woman.Old Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Domperidone + ParacetamolIt is a combinatation of D2 receptor antagonist Domeperidone and analgesics antipyretics Paracetamol.
1.Acute migraine attack
2.Headache associated with tension
3.Menstrual & Pre-menstrual cephalalgia
4.Pyrexia associated with nausea and vomiting
Interactions for Domperidone + ParacetamolN/ATypical Dosage for Domperidone + ParacetamolAdults:1 - 2 tablet at the onset of attack and if needed repeat the dose every 6 hours.
12-15 Years: 1 tablet at the onset of attack, maximum 3 tablets in 24 hours.
Liquid: 1-2 teaspoonfuls to be taken 3-4 times daily depending on the age and severity of the disease.
Schedule of Domperidone + ParacetamolN/AStorage Requirements for Domperidone + ParacetamolN/AEffects of Missed Dosage of Domperidone + ParacetamolN/AEffects of Overdose of Domperidone + ParacetamolN/A
DomperidoneAbout DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
Special Precautions while taking Domperidone1.Hepatic impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents.
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Domperidone + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including domperidone + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for domperidone + paracetamol and other medicines and health products. Home delivery services for domperidone + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take domperidone + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for domperidone + paracetamol before they complete the sale. You can get this information while placing the order for domperidone + paracetamol with the pharmacy.
Domperidone + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for domperidone + paracetamol might be better known than domperidone + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have domperidone + paracetamol in stock, you can ask for one of the branded alternatives for domperidone + paracetamol.