Drotrecogin alfa Pharmacology

Drotrecogin alfa

About Drotrecogin alfa
Recombinant form of human activated protein C,belongs to serine protease class, Anti-thrombotic, anti-inflammatory, and profibrinolytic.
Mechanism of Action of Drotrecogin alfa
It activate the protein kinase C which exert an antithrombotic effect by inhibiting factors Va and VIII a. It has indirect profibrinolytic activity through the inhibition of plasminogen activator-1 and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor
Pharmacokinets of Drotrecogin alfa
Onset of Action for Drotrecogin alfa
Duration of Action for Drotrecogin alfa
Half Life of Drotrecogin alfa
Side Effects of Drotrecogin alfa
Contra-indications of Drotrecogin alfa
1. Hyper sensitivity to the drug
2. Active internal bleeding
3. Intracranial surgery
4. Intraspinal surgery
5. Head trauma
6. Intracranial neoplasm
7. Mass lesion
Special Precautions while taking Drotrecogin alfa
1. Bleeding
2. Hepatic disease
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Drotrecogin alfa
Severe sepsis (sepsis associated with acute organ dysfunction) who have high risk of death.
Interactions for Drotrecogin alfa
Thrombolytics (e.g. streptokinase, tPA, rPA); oral anticoagulants (warfarin); hirudins, antithrombin, aspirin, and other anti-platelet agents; glycoprotein IIb/IIIa antagonists (e.g. abciximab, eptifibatide, tirofiban) and prostacyclins (e.g. iloprost): Use with caution.
Heparin: There was no observed increase in the risk of bleeding events reported as serious adverse events in drotrecogin alfa (activated) patients receiving heparin. The effects of prophylactic low dose heparin and other coagulation-active medications on the efficacy of drotrecogin alfa (activated) have not been evaluated in a randomized controlled clinical trial.
Typical Dosage for Drotrecogin alfa
24mg/kg/hr for a total duration of 96 hours
Schedule of Drotrecogin alfa
Storage Requirements for Drotrecogin alfa
Effects of Missed Dosage of Drotrecogin alfa
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Drotrecogin alfa
Give symptomatic and supportive treatment

Home Delivery for Drotrecogin alfa in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including drotrecogin alfa.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drotrecogin alfa and other medicines and health products. Home delivery services for drotrecogin alfa may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take drotrecogin alfa only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drotrecogin alfa before they complete the sale. You can get this information while placing the order for drotrecogin alfa with the pharmacy.

Drotrecogin alfa is a generic medicine name and there are several brands available for it. Some of the brands for drotrecogin alfa might be better known than drotrecogin alfa itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotrecogin alfa in stock, you can ask for one of the branded alternatives for drotrecogin alfa.