Sibutramine Pharmacology


About Sibutramine
A centrally-acting serotonin-norepinephrine reuptake inhibitor, Anorexiant(Antiobesity).
Mechanism of Action of Sibutramine
It exerts anorectic action by inhibiting the reuptake of both nor adrenaline and serotonin. It also stimulates thermogenesis by indirectly activating ?3 system in adipose tissue.
Pharmacokinets of Sibutramine
Absorption: About 77% of a dose is rapidly absorbed orally Distribution: Widely distributed in the body (especially in to liver and kidney) in a protein bound form, Metabolism: Metabolized in to active metabolites in the liver, Excretion: Excreted mainly through urine.
Onset of Action for Sibutramine
Duration of Action for Sibutramine
Half Life of Sibutramine
Side Effects of Sibutramine
1. Dry mouth
2. Anxiety
3. Insomnia
4. Mood swings
5. Constipation
6. Chest pain
7. Mild increase in BP and heart rate
8. Altered liver function tests
9. Allergic reactions
Contra-indications of Sibutramine
1. Hypersensitivity to the drug
2. In patient`s receiving MAO inhibitors
3. Patients receiving other centrally acting appetite suppressants
4. Anorexia nervosa
5. In patients with coronary artery diseases, heart failure, arrhythmias and stroke
6. Severe renal impairment
7. Severe hepatic impairment
8. History of Seizures
Special Precautions while taking Sibutramine
1. Narrow angle glaucoma
2. Regularly monitors BP during therapy
3. Exclude organic causes of obesity like hypothyroidism
4. Avoid driving or using hazardous machinery which requires mental alertness
5. Hepatic impairment
6. Renal impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Sibutramine
1. Management of obesity, including weight loss and maintenance of weight loss; should be used in conjunction with a reduced calorie diet
Interactions for Sibutramine
CNS active drugs: Use with caution with other CNS active drugs. It should not be used with MAOIs. Atleast 2-weeks should elapse between discontinuation of a MAOI and initiation of treatment with sibutramine.
Drugs that may raise blood pressure and/or heart rate: Caution should be used when prescribing sibutramine to patients who use these medications.
Drugs that inhibit cytochrome P450 (3A4) metabolism (Erythromycin, ketoconazole): Concomitant administration of these drugs with sibutramine is not recommended since there is a potential for interaction.
Cimetidine: Efficacy of cimetidine enhanced.
Alcohol: Concomitant use with alcohol is not recommended.
Oral contraceptives: Sibutramine does not inhibit suppression of ovulation by oral contraceptives.
Typical Dosage for Sibutramine
Oral: 10mg once daily with or without food. Dose may increase to 15mg daily after 4 weeks if weight loss is inadequate. Patients who don`t tolerate the 10mg dose may receive 5mg daily. Should not use doses above 15mg daily.
Schedule of Sibutramine
Storage Requirements for Sibutramine
Store at controlled room temperature at a range of 15 to 30 degree C. Protect from moisture, light, and excess heat. Keep out of reach of children.
Effects of Missed Dosage of Sibutramine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sibutramine
Provide supportive measures and symptomatic treatment. Establish air way, monitor cardiac and vital signs. Beta blockers may be use with caution to control elevated BP and tachycardia.

Home Delivery for Sibutramine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sibutramine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sibutramine and other medicines and health products. Home delivery services for sibutramine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sibutramine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sibutramine before they complete the sale. You can get this information while placing the order for sibutramine with the pharmacy.

Sibutramine is a generic medicine name and there are several brands available for it. Some of the brands for sibutramine might be better known than sibutramine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sibutramine in stock, you can ask for one of the branded alternatives for sibutramine.