Dimenhydrinate Pharmacology


About Dimenhydrinate
Muscarinic antagonist,Ethanolamine derivative, First Generation H1 Antagonist , Anti histamine, Deliriants, Antiemetics,Antivertigo.
Mechanism of Action of Dimenhydrinate
Antiemetic and antivertigo action: Dimenhydrinate is a salt of Diphenhydramine and Chlorotheophyllinate. Dimenhydrinate produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Antiallergics: Dimenhydrinate is a potent H1 receptor antihistaminic agent. It has anticholinergic and central sedative action also.
Migraine: Dimenhydrinate is used in migraine due to its sedative as well as antiemetic actions.
Pharmacokinets of Dimenhydrinate
Absorption: Dimenhydrinate is well absorbed after oral administration. Distribution: It is distributed widely in the body and crosses the placenta. Metabolism: Dimenhydrinate undergoes metabolism in the liver. Excretion: Excreted mainly in urine.
Onset of Action for Dimenhydrinate
15 - 30 minutes
Duration of Action for Dimenhydrinate
3 - 6 hours
Half Life of Dimenhydrinate
1 - 4 hours
Side Effects of Dimenhydrinate
3.Dry mouth
8.Tightness of chest
10.Blurred vision
11.Abdominal discomfort
Contra-indications of Dimenhydrinate
Hypersensitivity to Dimenhydrinate or related drug
Special Precautions while taking Dimenhydrinate
1.Seizure disorder
2.Prostate hypertrophy
3.Acute angle closure glaucoma
4.Urinary retention
7.Hepatic impairment
10.Irregular heart beat
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Children Related Information
Use with caution
Children below 2 years: contraindicated
NEONATES: contraindicated
Indications for Dimenhydrinate
1. Treatment of nausea, vomiting and dizziness associated with motion sickness.
2. Treatment of nausea and vomiting in Meniere`s disease
Interactions for Dimenhydrinate
Alchohol & other CNS depressants like barbiturates, analgesics, sedatives neuroleptics: CNS depressant effect enhanced.
MAOIs, Atropine & TCAs: Antimuscarinic effect enhanced.
Aminoglycosides: Ototoxicity masked, irreversible damage may occur.
Aminophylline, Hydrocortisone, Phenothiazines and some soluble barbiturates: Incompatible with these in solution.
Typical Dosage for Dimenhydrinate
Adults: 50 - 100 mg 6 - 8 hours daily
For motion sickness drug should be administered half an hour before traveling.
Treatment of nausea and vomiting in Meniere`s disease: 50 mg IM for acute attack
Maintenance dose: 75 - 150 mg / day in 3 divided doses
Children: 1.5 mg / kg / day in 3 divided doses.
Schedule of Dimenhydrinate
Storage Requirements for Dimenhydrinate
Store at 20 - 25 degree C in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Dimenhydrinate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimenhydrinate
Give supportive measures and symptomatic treatment. Gastric lavage can be done to remove the drug from the body. To treat seizure Diazepam or Phenytoin is given to the patient.

Home Delivery for Dimenhydrinate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dimenhydrinate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dimenhydrinate and other medicines and health products. Home delivery services for dimenhydrinate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dimenhydrinate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dimenhydrinate before they complete the sale. You can get this information while placing the order for dimenhydrinate with the pharmacy.

Dimenhydrinate is a generic medicine name and there are several brands available for it. Some of the brands for dimenhydrinate might be better known than dimenhydrinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dimenhydrinate in stock, you can ask for one of the branded alternatives for dimenhydrinate.