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- Pharmacology For Vit B12 + Biotin
Vit B12 + Biotin Pharmacology
Vit B12 + BiotinAbout Vit B12 + BiotinN/AMechanism of Action of Vit B12 + BiotinN/APharmacokinets of Vit B12 + BiotinN/AOnset of Action for Vit B12 + BiotinN/ADuration of Action for Vit B12 + BiotinN/AHalf Life of Vit B12 + BiotinN/ASide Effects of Vit B12 + BiotinN/AContra-indications of Vit B12 + BiotinN/ASpecial Precautions while taking Vit B12 + BiotinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Vit B12 + BiotinN/AInteractions for Vit B12 + BiotinN/ATypical Dosage for Vit B12 + BiotinN/ASchedule of Vit B12 + BiotinN/AStorage Requirements for Vit B12 + BiotinN/AEffects of Missed Dosage of Vit B12 + BiotinN/AEffects of Overdose of Vit B12 + BiotinN/A
Vit B12About Vit B12N/AMechanism of Action of Vit B12Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.Pharmacokinets of Vit B12Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12N/ADuration of Action for Vit B12N/AHalf Life of Vit B12N/ASide Effects of Vit B121. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B121. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B121. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Vit B121. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12N/ATypical Dosage for Vit B12I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12CStorage Requirements for Vit B12Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.Effects of Missed Dosage of Vit B12Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B12Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.
BiotinAbout BiotinN/AMechanism of Action of BiotinBiotin excerts it`s pharmacological action by influencing metabolic reactions. It acts as a coenzyme for carbohydrate, fat, and protein metabolism. It is required for cell growth and production of fatty acids. It is required for healthy maintenance of hair, skin, sweat glands, nerve tissue, and bone marrow. It also helps in the transfer of carbon dioxide and in the maintenance of a steady blood sugar level.Pharmacokinets of BiotinAbsorption: Well absorbed orally, Excretion: Extra drug is excreted unchanged in urine.Onset of Action for BiotinN/ADuration of Action for BiotinN/AHalf Life of BiotinN/ASide Effects of BiotinN/AContra-indications of BiotinHypersensitivity of any biotin products.Special Precautions while taking BiotinN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Biotin1.Biotin deficiency
4.Prevent diabetic neuropathy and lower blood glucose levels in diabetic patients
Interactions for BiotinN/ATypical Dosage for BiotinOral: 30 to 70mcg daily. Increased up to 300mcg/day if required based on the severity of deficiency.
Pregnancy: 30mcg daily
Lactation: 35mcg daily
Prevent brittle nails: 2.5mg/day.
Schedule of BiotinC1Storage Requirements for BiotinStore in a cool dry area in a well closed container. Protects from moisture, light and direct heat.Effects of Missed Dosage of BiotinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BiotinProvide symptomatic treatment and supportive measures.
Home Delivery for Vit B12 + Biotin in Your City
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