Nicotinamide Pharmacology

Nicotinamide

About Nicotinamide
Water Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid.
Mechanism of Action of Nicotinamide
Nicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Nicotinamide
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Nicotinamide
N/A
Duration of Action for Nicotinamide
N/A
Half Life of Nicotinamide
N/A
Side Effects of Nicotinamide
1.Activation of peptic ulcer
2.Nausea
3.Vomiting
4.Diarrhoea
5.Headache
6.Hypotension
7.Arrhythmias
8.Hepatic impairment
Contra-indications of Nicotinamide
1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage
Special Precautions while taking Nicotinamide
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nicotinamide
1.Pellagra
2.Niacin deficiency
3.Hartnup disease
Interactions for Nicotinamide
N/A
Typical Dosage for Nicotinamide
Pellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Nicotinamide
N/A
Storage Requirements for Nicotinamide
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Nicotinamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nicotinamide
Provide supportive measures and symptomatic treatment.

Home Delivery for Nicotinamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nicotinamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nicotinamide and other medicines and health products. Home delivery services for nicotinamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nicotinamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nicotinamide before they complete the sale. You can get this information while placing the order for nicotinamide with the pharmacy.

Nicotinamide is a generic medicine name and there are several brands available for it. Some of the brands for nicotinamide might be better known than nicotinamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nicotinamide in stock, you can ask for one of the branded alternatives for nicotinamide.