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- Pharmacology For Flunarizine
FlunarizineAbout FlunarizineCalcium channel blocker and H1 blocker, Diphenyl Piperazine derivative, Antivertigo,Anti migraine, vasodilator, anticonvulsant.Mechanism of Action of FlunarizineFlunarizine is the diflourinated derivative of Cinnarizine. Flunarizine has H1 antihistaminic, sedative and calcium channel blocking actions. It is a cerebro selective calcium ion (Ca +2) channel blocker. It reduces the frequency of migraine attacks by reducing intracellular Ca +2 overload due to brain hypoxia and other causes. It inhibits the vasospasm induced by mediators such as serotonin and prostaglandins.
Antihistamines are the mainstay of the treatment of vertigo. Flunarizine suppresses end organ receptors or inhibit central cholinergic pathway in vestibular nuclei and produces antivertigo action
Pharmacokinets of FlunarizineAbsorption: Flunarizine is well absorbed after oral administration. Metabolism: Considerable amount undergoes hepatic metabolism.Onset of Action for Flunarizine60 minutesDuration of Action for Flunarizine3 weeksHalf Life of Flunarizine19 daysSide Effects of Flunarizine1.Nausea
Contra-indications of Flunarizine1.Hypersensitivity to Flunarizine
Special Precautions while taking Flunarizine1. Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities.Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationNULL
NEONATES: contraindicatedIndications for Flunarizine1.Prophylaxis of Migraine
2.Prophylaxis of vertigo
3.Prophylaxis of vestibular disorders
4.Prophylaxis of peripheral and cerebrovascular disorders.
Interactions for FlunarizinePhenytoin, Carbamazepine, Valproic acid: Decrease efficacy of flunarizine.Typical Dosage for FlunarizineAdult: 5 - 10 mg once daily in the evening.Schedule of FlunarizineHStorage Requirements for FlunarizineStore at 15 - 30 degree C. Protect from light and moisture. Keep out of the reach of childrenEffects of Missed Dosage of FlunarizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FlunarizineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by emesis. Absorption of the drug can be reduced by administration of charcoal.
Home Delivery for Flunarizine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flunarizine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flunarizine and other medicines and health products. Home delivery services for flunarizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take flunarizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flunarizine before they complete the sale. You can get this information while placing the order for flunarizine with the pharmacy.
Flunarizine is a generic medicine name and there are several brands available for it. Some of the brands for flunarizine might be better known than flunarizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flunarizine in stock, you can ask for one of the branded alternatives for flunarizine.