Flunarizine Pharmacology

Flunarizine

About Flunarizine

Calcium channel blocker and H1 blocker, Diphenyl Piperazine derivative, Antivertigo,Anti migraine, vasodilator, anticonvulsant.

Mechanism of Action of Flunarizine

Flunarizine is the diflourinated derivative of Cinnarizine. Flunarizine has H1 antihistaminic, sedative and calcium channel blocking actions. It is a cerebro selective calcium ion (Ca +2) channel blocker. It reduces the frequency of migraine attacks by reducing intracellular Ca +2 overload due to brain hypoxia and other causes. It inhibits the vasospasm induced by mediators such as serotonin and prostaglandins.
Antihistamines are the mainstay of the treatment of vertigo. Flunarizine suppresses end organ receptors or inhibit central cholinergic pathway in vestibular nuclei and produces antivertigo action

Pharmacokinets of Flunarizine

Absorption: Flunarizine is well absorbed after oral administration. Metabolism: Considerable amount undergoes hepatic metabolism.

Onset of Action for Flunarizine

60 minutes

Duration of Action for Flunarizine

3 weeks

Half Life of Flunarizine

19 days

Side Effects of Flunarizine

1.Nausea
2.Vomiting
3.Drowsiness
4.Headache
5.Abdominal disturbances
6.Weight gain
7.Insomnia
8.Depression
9.Rash
10.Tremor
11.Asthenia
12.Dry mouth
13.Extrapyramidal reactions

Contra-indications of Flunarizine

1.Hypersensitivity to Flunarizine
2.Depression
3.Parkinson`s disease

Special Precautions while taking Flunarizine

1. Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities.

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated.

Children Related Information

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NEONATES: contraindicated

Indications for Flunarizine

1.Prophylaxis of Migraine
2.Prophylaxis of vertigo
3.Prophylaxis of vestibular disorders
4.Prophylaxis of peripheral and cerebrovascular disorders.

Interactions for Flunarizine

Phenytoin, Carbamazepine, Valproic acid: Decrease efficacy of flunarizine.

Typical Dosage for Flunarizine

Adult: 5 - 10 mg once daily in the evening.

Schedule of Flunarizine

Storage Requirements for Flunarizine

Store at 15 - 30 degree C. Protect from light and moisture. Keep out of the reach of children

Effects of Missed Dosage of Flunarizine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Flunarizine

Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by emesis. Absorption of the drug can be reduced by administration of charcoal.

Home Delivery for Flunarizine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flunarizine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flunarizine and other medicines and health products. Home delivery services for flunarizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take flunarizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flunarizine before they complete the sale. You can get this information while placing the order for flunarizine with the pharmacy.

Flunarizine is a generic medicine name and there are several brands available for it. Some of the brands for flunarizine might be better known than flunarizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flunarizine in stock, you can ask for one of the branded alternatives for flunarizine.