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- Pharmacology For Vitamin B-Complex + Vitamin C + Vitamin E
Vitamin B-Complex + Vitamin C + Vitamin E Pharmacology
Vitamin B-Complex + Vitamin C + Vitamin EAbout Vitamin B-Complex + Vitamin C + Vitamin EN/AMechanism of Action of Vitamin B-Complex + Vitamin C + Vitamin EN/APharmacokinets of Vitamin B-Complex + Vitamin C + Vitamin EN/AOnset of Action for Vitamin B-Complex + Vitamin C + Vitamin EN/ADuration of Action for Vitamin B-Complex + Vitamin C + Vitamin EN/AHalf Life of Vitamin B-Complex + Vitamin C + Vitamin EN/ASide Effects of Vitamin B-Complex + Vitamin C + Vitamin EN/AContra-indications of Vitamin B-Complex + Vitamin C + Vitamin EN/ASpecial Precautions while taking Vitamin B-Complex + Vitamin C + Vitamin EN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Vitamin B-Complex + Vitamin C + Vitamin EN/AInteractions for Vitamin B-Complex + Vitamin C + Vitamin EN/ATypical Dosage for Vitamin B-Complex + Vitamin C + Vitamin EN/ASchedule of Vitamin B-Complex + Vitamin C + Vitamin EN/AStorage Requirements for Vitamin B-Complex + Vitamin C + Vitamin EN/AEffects of Missed Dosage of Vitamin B-Complex + Vitamin C + Vitamin EN/AEffects of Overdose of Vitamin B-Complex + Vitamin C + Vitamin EN/A
Vitamin B-ComplexAbout Vitamin B-ComplexVitamin B-complex are group of vitamins, which include Thiamine (B1),Riboflavin (B2),Niacin (B3),Pantothenic acid (B5),Pyridoxine (B6),Cyanocobalamin (B12),Folic acid and Biotin.
These vitamins are essential for the breakdown of carbohydrates into glucose (this provides energy for the body),the breakdown of fats and proteins (which aids the normal functioning of the nervous system),muscle tone in the stomach and intestinal tract,Skin,Hair,Eyes,Mouth and Liver
Mechanism of Action of Vitamin B-ComplexN/APharmacokinets of Vitamin B-ComplexN/AOnset of Action for Vitamin B-ComplexN/ADuration of Action for Vitamin B-ComplexN/AHalf Life of Vitamin B-ComplexN/ASide Effects of Vitamin B-Complex1.Drowsiness
5.Numbness of the skin
Contra-indications of Vitamin B-ComplexHypersensitivity to the ingredient of Vitamin B-complexSpecial Precautions while taking Vitamin B-Complex1.Pernecious anaemia
2.Patient receiving dialysisPregnancy Related InformationMay be used.Old Age Related InformationMay be used.Breast Feeding Related InformationMay be used.Children Related InformationMay be used.Indications for Vitamin B-Complex1.Vitamin deficiency states
2. As an adjuvant to antibiotic therapy
3. Combinations with lactobacillus are indicated in aphthous stomatitis, thrush.Interactions for Vitamin B-ComplexSulfinpyrazone: Uricosuric effect of sulfinpyrazone may be inhibited by niacin.
Levodopa: Pyridoxine reduces efficacy of levodopa. Avoid supplemental vitamins that contain greater then 5 mg pyridoxine in the daily dose.
Phenobarbital: Serum levels of Phenobarbital may be decreased if used concomitantly with pyridoxine.
Phenytoin: Pyridoxine decreases serum levels of phenytoin.
Dapsone: PABA antagonizes anti-malarial effect of dapsone.
Typical Dosage for Vitamin B-ComplexI tablet /daySchedule of Vitamin B-ComplexN/AStorage Requirements for Vitamin B-ComplexStore at room temperature. Keep out of the reach of children.Protect from heat, light and moisture.Effects of Missed Dosage of Vitamin B-ComplexTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin B-ComplexGive supportive measures and symptomatic treatment.
Vitamin CAbout Vitamin CWater soluble vitamin, antioxidant.Mechanism of Action of Vitamin CVitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.Pharmacokinets of Vitamin CAbsorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin CN/ADuration of Action for Vitamin CN/AHalf Life of Vitamin CN/ASide Effects of Vitamin C1. Discomfort at injection site
2. Acid urine
3. Renal calculi
Contra-indications of Vitamin CNo known contraindicationsSpecial Precautions while taking Vitamin C1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vitamin C1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries
Interactions for Vitamin COral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.Typical Dosage for Vitamin COral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.
Schedule of Vitamin CC1 (Oral)
C (Parenteral)Storage Requirements for Vitamin CStore in a cool dry area in a well closed container. Protects from moisture, light and direct heat.Effects of Missed Dosage of Vitamin CTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin CDiscontinue the therapy and provide symptomatic and supportive measures.
Vitamin EAbout Vitamin EN/AMechanism of Action of Vitamin EVitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.Pharmacokinets of Vitamin EAbsorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin EN/ADuration of Action for Vitamin EN/AHalf Life of Vitamin EN/ASide Effects of Vitamin E1. Fatigue
6. Blurred vision
Contra-indications of Vitamin E1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related InformationMay be usedOld Age Related InformationN/ABreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Vitamin E1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant
Interactions for Vitamin EOral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.
Typical Dosage for Vitamin EOral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.
Schedule of Vitamin EC1Storage Requirements for Vitamin EStore in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Vitamin ETake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin EProvide supportive measures and symptomatic treatment.
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