Divalproex Pharmacology


About Divalproex
Carboxylic acid derivative, Histone Deacetylase Inhibitor, Anticonvulsants, Mood stabilizers ,antimigraine agent.
Mechanism of Action of Divalproex
Divalproex is an antiepileptic agent. It dissociates in the gastrointestinal tract into 2 molecules of Valproic acid and this Valproic acid produces therapeutic response by following mechanism. Valproic acid prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or by decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency neuronal discharge.It blocks the propagation of neuronal impulses.
It also modulates neurotransmitter release and neuronal bursting through an effect on voltage gated and receptor gated calcium channels.
Valproic acid enhances the release and synthesis of inhibitory neurotransmitter GABA and inhibits its degradation. This will results in an increased concentration of inhibitory neurotransmitter GABA.
Divalproex is useful in migraine prophylaxis.
Pharmacokinets of Divalproex
Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in urine and small amount in faeces, exhaled air and breast milk.
Onset of Action for Divalproex
Duration of Action for Divalproex
Half Life of Divalproex
Side Effects of Divalproex
8.Abdominal cramps
11.Loss of hair
Contra-indications of Divalproex
1.Hypersensitivity to Divalproex
2.Hepatic impairment
Special Precautions while taking Divalproex
1.Mental retarded children taking antiepileptic drugs
2.Congenital metabolic disorders
3.Slowly withdraw the drug with caution
4.Use with caution when driving vehicle, operating machine or performing other hazardous activities
5.Monitor liver function before and during the treatment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
CHILDREN below 2 years: contraindicated
Indications for Divalproex
1.For the treatment of epilepsy (Primary generalised seizure, Petitmal epilepsy, Infantile spasm, Grandmal epilepsy, Myoclonic seizure and psychomotor seizure)
3.Migraine prophylaxis
Interactions for Divalproex
Typical Dosage for Divalproex
Anticonvulsant: Initial dose: 10 - 15 mg / kg / day in 3 divided doses. Dose can be increased by 5 - 10 mg /kg/day every 7 days until seizures are controlled.
Maximum dose: 60mg / kg/day
Mania: 750 mg / day in divided doses
Migraine prophylaxis: 500mg / day in 2 divided doses if needed dose can be increased up to 1 g.
CHILDREN above 10 years:
Anticonvulsant: Initial dose: 10 - 15 mg / kg / day in 3 divided doses. Dose can be increased by 5 - 10 mg /kg/day every 7 days until seizures are controlled.
Maximum dose: 60mg / kg/day
Schedule of Divalproex
Storage Requirements for Divalproex
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Divalproex
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Divalproex
Give supportive measures and symptomatic treatment. Naloxone can be given to reverse CNS, respiratory depression and anticonvulsant action of Valproic acid.

Home Delivery for Divalproex in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including divalproex.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for divalproex and other medicines and health products. Home delivery services for divalproex may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take divalproex only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for divalproex before they complete the sale. You can get this information while placing the order for divalproex with the pharmacy.

Divalproex is a generic medicine name and there are several brands available for it. Some of the brands for divalproex might be better known than divalproex itself. If the pharmacy that's willing to deliver medicines to your home doesn't have divalproex in stock, you can ask for one of the branded alternatives for divalproex.