Iron (Ferrous glycine sulphate) + Folic acid Pharmacology

Iron (Ferrous glycine sulphate) + Folic acid

About Iron (Ferrous glycine sulphate) + Folic acid
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Mechanism of Action of Iron (Ferrous glycine sulphate) + Folic acid
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Pharmacokinets of Iron (Ferrous glycine sulphate) + Folic acid
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Onset of Action for Iron (Ferrous glycine sulphate) + Folic acid
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Duration of Action for Iron (Ferrous glycine sulphate) + Folic acid
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Half Life of Iron (Ferrous glycine sulphate) + Folic acid
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Side Effects of Iron (Ferrous glycine sulphate) + Folic acid
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Contra-indications of Iron (Ferrous glycine sulphate) + Folic acid
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Special Precautions while taking Iron (Ferrous glycine sulphate) + Folic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Iron (Ferrous glycine sulphate) + Folic acid
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Interactions for Iron (Ferrous glycine sulphate) + Folic acid
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Typical Dosage for Iron (Ferrous glycine sulphate) + Folic acid
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Schedule of Iron (Ferrous glycine sulphate) + Folic acid
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Storage Requirements for Iron (Ferrous glycine sulphate) + Folic acid
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Effects of Missed Dosage of Iron (Ferrous glycine sulphate) + Folic acid
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Effects of Overdose of Iron (Ferrous glycine sulphate) + Folic acid
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Iron (Ferrous glycine sulphate)

About Iron (Ferrous glycine sulphate)
Oral iron preparation, An iron-containing salt, Antianemic,hematinic
Mechanism of Action of Iron (Ferrous glycine sulphate)
Ferrous glycine sulfate is a chelate of ferrous sulfate and glycine used as a source of iron for iron-deficiency anaemia. It is given by mouth in doses containing the equivalent of up to 150 mg of iron daily. It exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
It has relatively high bioavailability in the presence of dietary inhibitors. Chelates prevent iron from binding to inhibitors in food or precipitating as insoluble ferric hydroxide in the pH of the small intestine.
Pharmacokinets of Iron (Ferrous glycine sulphate)
Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.
Onset of Action for Iron (Ferrous glycine sulphate)
N/A
Duration of Action for Iron (Ferrous glycine sulphate)
N/A
Half Life of Iron (Ferrous glycine sulphate)
N/A
Side Effects of Iron (Ferrous glycine sulphate)
1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations
Contra-indications of Iron (Ferrous glycine sulphate)
1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Ferrous glycine sulphate)
1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related Information
May be used
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Iron (Ferrous glycine sulphate)
1. Iron deficiency
2. Iron deficiency anaemia
Interactions for Iron (Ferrous glycine sulphate)
N/A
Typical Dosage for Iron (Ferrous glycine sulphate)
Adult: I capsule or 10ml once or twice daily after meals.
Children: 5-10 ml twice daily after meals.
Schedule of Iron (Ferrous glycine sulphate)
N/A
Storage Requirements for Iron (Ferrous glycine sulphate)
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Iron (Ferrous glycine sulphate)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Iron (Ferrous glycine sulphate)
Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl.

Folic Acid

About Folic Acid
Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.
Mechanism of Action of Folic Acid
Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinets of Folic Acid
Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic Acid
Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic Acid
Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic Acid
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Side Effects of Folic Acid
N/A
Contra-indications of Folic Acid
N/A
Special Precautions while taking Folic Acid
1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Folic Acid
1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid
1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic Acid
Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic Acid
C1 (Oral)
C (Parenteral)
Storage Requirements for Folic Acid
Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.
Effects of Missed Dosage of Folic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Folic Acid
Relatively non toxic. Provide symptomatic treatment and supportive measures.

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