Topiramate Pharmacology


About Topiramate
A sulfamate-substituted monosaccharide, Carbonic anhydrase inhibitor, Anticonvulsant,antimigraine.
Mechanism of Action of Topiramate
Topiramate acts on the motor cortex where it stabilizes neuronal membrane and inhibits the spread of seizure discharge. It prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency neuronal discharge. It enhances the inhibitory neurotransmitter GABA and inhibits the excitatory glutamate receptors. Topiramate is also used in migraine prophylaxis.
Topiramate also has weak carbonic anhydrase inhibitory activity.

Pharmacokinets of Topiramate
Absorption: Topiramate is well absorbed after oral administration.
Distribution: It is mainly distributed in the body in unbound form.
Metabolism: It undergoes insignificant metabolism.
Excretion: It is excreted mainly in urine.

Onset of Action for Topiramate
Duration of Action for Topiramate
Half Life of Topiramate
21 hours
Side Effects of Topiramate
1. Dizziness
2. Confusion
3. Ataxia
4. Difficulty with concentrations
5. Depression
6. Paresthesia
7. Sedation
8. Psychomotor slowing
9. Personality disorder
10. Somnolence
11. Tremor
12. Nausea
13. Abdominal pain
14. Blurred vision
15. Renal calculus
16. Upper respiratory tract infection
17. Fatigue

Contra-indications of Topiramate
1. Hypersensitivity to Topiramate
Special Precautions while taking Topiramate
1. Hepatic impairment
2. Renal impairment
3. Slowly withdraw the drug with caution
4. Maintain proper hydration
5. Use caution when driving vehicle, operating machine or activities requiring mental alertness

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Above 2 years : Use with caution
NEONATES: Contraindicated
Indications for Topiramate
1. Anticonvulsant (Simple partial seizure, complex partial seizure, Generalised tonic-clonic seizure and Myoclonic seizure)
2. Migraine prophylaxis
Interactions for Topiramate
Typical Dosage for Topiramate
Adults: Initial dose: 25 mg /day for 1 week increase the dose by 25 - 50 mg /day every 1 - 2 week until effective therapeutic response is obtained.
Maintenance dose: 100 - 200 mg two times daily.
Maximum dose: 400 mg two times daily.
Migraine prophylaxis: 100 - 200 mg / day

Children : Initial dose: 25 mg /day at night for 1 week increase the dose by 1 - 3 mg/ kg bodyweight /day every 1 - 2 week until effective therapeutic response is obtained.
Recommended daily dose: 5 - 9 mg / kg / day in 2 divided doses
Schedule of Topiramate
Storage Requirements for Topiramate
Store at 15 - 30 degree C. Protect from light and moisture.
Effects of Missed Dosage of Topiramate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Topiramate
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Haemodialysis can be done if necessary.

Home Delivery for Topiramate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including topiramate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for topiramate and other medicines and health products. Home delivery services for topiramate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take topiramate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for topiramate before they complete the sale. You can get this information while placing the order for topiramate with the pharmacy.

Topiramate is a generic medicine name and there are several brands available for it. Some of the brands for topiramate might be better known than topiramate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have topiramate in stock, you can ask for one of the branded alternatives for topiramate.