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- Pharmacology For Chromium + Copper + Manganese + Zinc
Chromium + Copper + Manganese + Zinc Pharmacology
Chromium + Copper + Manganese + ZincAbout Chromium + Copper + Manganese + ZincN/AMechanism of Action of Chromium + Copper + Manganese + ZincN/APharmacokinets of Chromium + Copper + Manganese + ZincN/AOnset of Action for Chromium + Copper + Manganese + ZincN/ADuration of Action for Chromium + Copper + Manganese + ZincN/AHalf Life of Chromium + Copper + Manganese + ZincN/ASide Effects of Chromium + Copper + Manganese + ZincN/AContra-indications of Chromium + Copper + Manganese + ZincN/ASpecial Precautions while taking Chromium + Copper + Manganese + ZincN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Chromium + Copper + Manganese + Zinc1.Supplement to IV parenteral nutrition solution
2.Deficiency of trace elements
Interactions for Chromium + Copper + Manganese + ZincN/ATypical Dosage for Chromium + Copper + Manganese + ZincAs directed by the PhysicianSchedule of Chromium + Copper + Manganese + ZincN/AStorage Requirements for Chromium + Copper + Manganese + ZincN/AEffects of Missed Dosage of Chromium + Copper + Manganese + ZincN/AEffects of Overdose of Chromium + Copper + Manganese + ZincN/A
ChromiumAbout ChromiumChromium is by far the most pivotal nutrient involved in sugar metabolism. Trivalent chromium is a part of glucose tolerance factor, an essential activator of insulin mediated reactions. Chromium improves insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increases in insulin sensitivity. Thus it helps to maintain normal glucose metabolism and peripheral nerve function. A number of clinical studies have been conducted which show that chromium is an effective therapy for both Type I and Type II diabetes. Except for supplementation, there is no good way to rebuild the body?s stockpile of chromium.
Deficiency symptoms: Impaired glucose tolerance, peripheral neuropathy, ataxia, confusion.
Over dosage symptoms: In normal therapeutic doses side effects have not been reported except occasional insomnia. In the event of over dosage - nausea, vomiting, GI ulcers, renal/hepatic damage, convulsion, coma may occur.
Mechanism of Action of ChromiumChromium picolinate acts by influencing carbohydrate metabolism. It stimulates Insulin mediated reactions and improves glucose tolerance. Chromium picolinate helps to improve; insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increase in insulin sensitivity. Thus it maintains normal glucose metabolism and peripheral nerve functions. It improves carbohydrate metabolism, increases energy and helps to control diabetes. It also helps to control weight.Pharmacokinets of ChromiumAbsorption: Well absorbed orally, Distribution: Widely distributed in the body in especially in to liver, kidney, bone, and spleen; normal plasma level is 1 to 5mcg/l. Excretion: Excreted mainly through urine.Onset of Action for ChromiumN/ADuration of Action for ChromiumN/AHalf Life of ChromiumN/ASide Effects of ChromiumN/AContra-indications of Chromium1. Hypersensitivity to the drug.Special Precautions while taking Chromium1. Prolonged therapy with the drug
3.In patients with Type II diabetes mellitus use of chromium picolinate is only under the direct medical supervision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Chromium1.Type I diabetes mellitus
2.Type II diabetes mellitus
Interactions for ChromiumN/ATypical Dosage for Chromium Oral: 200 mcg daily; increases up to 1mg daily if required.Schedule of ChromiumN/AStorage Requirements for ChromiumStore in a well closed container at a cool dry place.Effects of Missed Dosage of ChromiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ChromiumGive supportive measures and symptomatic treatment.
CopperAbout CopperThird most abundant essential trace mineral, A cofactor for many proteins, iron utilization enhancer, Copper deficiency.Mechanism of Action of CopperCopper is one of a relatively small group of metallic elements which are essential to human health. These elements, along with amino and fatty acids as well as vitamins, are required for normal metabolic processes.Pharmacokinets of CopperAbsorption:It is orally well absorbed.Onset of Action for CopperN/ADuration of Action for CopperN/AHalf Life of CopperN/ASide Effects of Copper1.Breathing problems
Contra-indications of CopperHypersensitivity to the drug
Special Precautions while taking Copper1.Blood pressure
2.Heart or blood vessel disease
Pregnancy Related Informationuse with cautionOld Age Related InformationN/ABreast Feeding Related Informationuse with cautionChildren Related InformationN/AIndications for Copper1. As a supplement for the prevention of cardiovascular disease, anemia, to enhance immunity, and to treat arthritis.Interactions for CopperN/ATypical Dosage for CopperAs directed by the physicianSchedule of CopperN/AStorage Requirements for CopperStore at 15 - 30 degree C. Protect from heat and light. Kept the container tightly closed after use. Keep out of the reach of childrenEffects of Missed Dosage of CopperTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CopperGive supportive measures and symptomatic treatment.
ManganeseAbout ManganeseMagnesium is essential for enzyme activity, calcium and potassium uptake, nerve transmission, bone formation and metabolism of carbohydrates and minerals. It is magnesium, not calcium, which helps form hard tooth enamel, resistant to decay. Like calcium and chloride, magnesium also plays a role in regulating the acid-alkaline balance in the body. High magnesium levels in drinking water have been linked to resistance to heart disease. Although it is found in many foods, including dairy products, nuts, vegetables, fish, meat and seafood, deficiencies are common in America due to soil depletion, poor absorption and lack of minerals in drinking water. A diet high in carbohydrates, oxalic acid in foods like raw spinach and phytic acid found in whole grains can cause deficiencies. An excellent source of usable magnesium is beef, chicken or fish broth. High amounts of zinc and vitamin D increase magnesium requirements. Magnesium deficiency can result in coronary heart disease, chronic weight loss, obesity, fatigue, epilepsy and impaired brain function. Chocolate cravings are a sign of magnesium deficiency.Mechanism of Action of ManganeseN/APharmacokinets of ManganeseN/AOnset of Action for ManganeseN/ADuration of Action for ManganeseN/AHalf Life of ManganeseN/ASide Effects of ManganeseN/AContra-indications of ManganeseN/ASpecial Precautions while taking ManganeseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for ManganeseN/AInteractions for ManganeseN/ATypical Dosage for ManganeseN/ASchedule of ManganeseN/AStorage Requirements for ManganeseN/AEffects of Missed Dosage of ManganeseN/AEffects of Overdose of ManganeseN/A
ZincAbout ZincTrance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.Mechanism of Action of ZincZinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.Pharmacokinets of ZincAbsorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.Onset of Action for ZincN/ADuration of Action for ZincN/AHalf Life of ZincN/ASide Effects of Zinc1. Nausea
3. Abdominal distress
4. Gastric ulceration
Contra-indications of ZincN/ASpecial Precautions while taking Zinc1.Don`t exceed prescribed dose
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
Interactions for ZincFluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.
Typical Dosage for ZincAdults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of ZincN/AStorage Requirements for ZincStore at a temperature below 30 degree CEffects of Missed Dosage of ZincTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ZincProvide symptomatic treatment and supportive measures
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