Hyoscine Butyl Bromide Pharmacology

Hyoscine Butyl Bromide

About Hyoscine Butyl Bromide
Anti-cholinergic, a tropane alkaloid, Antispasmodic in GI and GU spasm.
Mechanism of Action of Hyoscine Butyl Bromide

Hyoscine butyl bromide is an anticholinergic drug. It exerts its action by inhibiting muscarinic (cholinergic) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp.
It does not produce CNS effect.
Antivertigo: Hyoscine suppresses the end organ receptors or inhibit central cholinergic pathway in vestibular nuclei.
General anaesthesia: Once muscle paralysis is no longer desired, acetyl cholinesterase inhibitors are combined with a muscarinic receptor antagonist such as Glycopyrrolate or Hyoscine or Atropine to offset the muscarinic activation resulting from esterase inhibition
Pharmacokinets of Hyoscine Butyl Bromide
Onset of Action for Hyoscine Butyl Bromide
Within 60 minutes
Duration of Action for Hyoscine Butyl Bromide
6 hours
Half Life of Hyoscine Butyl Bromide
Side Effects of Hyoscine Butyl Bromide
1.Dry mouth
3.Blurred vision
4.Decreased sweating
5.Urinary hesitancy
6.Urine retention
Contra-indications of Hyoscine Butyl Bromide
1.Hypersensitivity to Hyoscine butyl bromide
3.Hypertrophy with urinary retention
5.Myasthenia gravis
7.Gastrointestinal obstruction
Special Precautions while taking Hyoscine Butyl Bromide
1. Cardiovascular diseases-Heart failure, Tachycardia
2. Thyrotoxicosis
3. Prostate hypertrophy
Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Hyoscine Butyl Bromide
1.Gastrointestinal spasm
2.Genitourinary spasm
Interactions for Hyoscine Butyl Bromide
Amantadine : Increase in anticholinergic side effects.
Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced.
Phenothiazines : Decreases antipsychotic activity, and increases anticholinergic activity.
TCAs : Increased anticholinergic side effects (dry mouth, constipation, urinary retention).
Typical Dosage for Hyoscine Butyl Bromide
Adult: 30 mg / day in 3 divided doses if needed dose can be increased to 80 mg / day in 4 divided doses.
Injection: 20 mg IV/IM if needed same dose can be repeated.
Maximum dose: 100 mg / day
Children: 30 mg / day in 3 divided doses
Infants: 15 mg / day in 3 divided doses
Schedule of Hyoscine Butyl Bromide
Storage Requirements for Hyoscine Butyl Bromide
Store in a cool dry place. Keep out of the reach of children
Effects of Missed Dosage of Hyoscine Butyl Bromide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Hyoscine Butyl Bromide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Hyoscine Butyl Bromide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hyoscine butyl bromide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hyoscine butyl bromide and other medicines and health products. Home delivery services for hyoscine butyl bromide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hyoscine butyl bromide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hyoscine butyl bromide before they complete the sale. You can get this information while placing the order for hyoscine butyl bromide with the pharmacy.

Hyoscine Butyl Bromide is a generic medicine name and there are several brands available for it. Some of the brands for hyoscine butyl bromide might be better known than hyoscine butyl bromide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hyoscine butyl bromide in stock, you can ask for one of the branded alternatives for hyoscine butyl bromide.