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- Pharmacology For Co Enzyme Q10 + Folic Acid + Minerals
Co Enzyme Q10 + Folic Acid + Minerals Pharmacology
Co Enzyme Q10 + Folic Acid + Minerals
About Co Enzyme Q10 + Folic Acid + MineralsN/AMechanism of Action of Co Enzyme Q10 + Folic Acid + MineralsN/APharmacokinets of Co Enzyme Q10 + Folic Acid + MineralsN/AOnset of Action for Co Enzyme Q10 + Folic Acid + MineralsN/ADuration of Action for Co Enzyme Q10 + Folic Acid + MineralsN/AHalf Life of Co Enzyme Q10 + Folic Acid + MineralsN/ASide Effects of Co Enzyme Q10 + Folic Acid + MineralsN/AContra-indications of Co Enzyme Q10 + Folic Acid + MineralsN/ASpecial Precautions while taking Co Enzyme Q10 + Folic Acid + MineralsN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Co Enzyme Q10 + Folic Acid + MineralsAntioxidantInteractions for Co Enzyme Q10 + Folic Acid + MineralsN/ATypical Dosage for Co Enzyme Q10 + Folic Acid + Minerals1 capsule / daySchedule of Co Enzyme Q10 + Folic Acid + MineralsN/AStorage Requirements for Co Enzyme Q10 + Folic Acid + MineralsN/AEffects of Missed Dosage of Co Enzyme Q10 + Folic Acid + MineralsN/AEffects of Overdose of Co Enzyme Q10 + Folic Acid + MineralsN/ACo Enzyme Q10
About Co Enzyme Q101,4-benzoquinone derivative, oil-soluble vitamin-like substance, Enzyme cofactors, powerful antioxidantMechanism of Action of Co Enzyme Q10Coenzyme Q10 is vital for the proper transfer of electrons within the mitochondrial oxidative respiratory chain there it passes reducing equivalents to acceptors such as Coenzyme Q: cytochrome c - oxidoreductase:
CoQH2+ 2 FeIII-cytochrome c ? CoQ + 2 FeII-cytochrome c. main function of this transport is adenosine triphosphate production. Coenzyme Q10 also increases adenosine triphosphate levels by preventing the loss of the adenine nucleotide pool from cardiac cells. Coenzyme Q10 has activity as an antioxidant scavenger and an indirect stabilizer of calcium channels to decrease calcium overload. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Pharmacokinets of Co Enzyme Q10Absorption- Poorly absorbed after oral administration. Excretion- Excreted through bile and fecesOnset of Action for Co Enzyme Q10N/ADuration of Action for Co Enzyme Q10N/AHalf Life of Co Enzyme Q10N/ASide Effects of Co Enzyme Q101. Nausea
2. Vomiting
3. Stomach upset
4. Heartburn
5. Diarrhea
6. Loss of appetite
7. Skin itching
8. Rash
9. Insomnia
10. Headache
11. Dizziness
12. Irritability
13. Increased light sensitivity of the eyes
14. Fatigue
15. Flu-like symptoms
Contra-indications of Co Enzyme Q10N/ASpecial Precautions while taking Co Enzyme Q10N/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Co Enzyme Q101. Dietary supplement
2. Antioxidant
3. Migraine headaches
4. Parkinson`s Disease
5. Mitochondrial Encephalomyopathies
6. Migraine
7. CHF
8. Hypertension
9. Diabetes
10. Cancer
Interactions for Co Enzyme Q10N/ATypical Dosage for Co Enzyme Q10Adult-
Oral-
Mitochondrial cytopathies: 150 mg per day or 2 mg per kg per day with titration up to 3,000 mg per day in some patients
Parkinson`s disease: 300 to 1,200 mg per day in four divided doses
Cardiovascular problems: 50 to 200 mg per day
Migraine 100 to 200 mg per day
Schedule of Co Enzyme Q10N/AStorage Requirements for Co Enzyme Q10Keep tightly closed in a dry place. Do not expose to excessive heat.Effects of Missed Dosage of Co Enzyme Q10Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of Co Enzyme Q10Give supportive measures and symptomatic treatment.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Minerals
About MineralsDietary mineral supplement, Nutritional supplement.Mechanism of Action of MineralsN/APharmacokinets of MineralsN/AOnset of Action for MineralsN/ADuration of Action for MineralsN/AHalf Life of MineralsN/ASide Effects of MineralsN/AContra-indications of MineralsN/ASpecial Precautions while taking MineralsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for MineralsN/AInteractions for MineralsN/ATypical Dosage for MineralsN/ASchedule of MineralsN/AStorage Requirements for MineralsN/AEffects of Missed Dosage of MineralsN/AEffects of Overdose of MineralsN/AHome Delivery for Co Enzyme Q10 + Folic Acid + Minerals in Your City
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