Valethamate Pharmacology


About Valethamate
Anticholinergic(antimuscarinic),a smooth muscle relaxant, Oxytocic,antispasmodic.
Mechanism of Action of Valethamate
Valethamate is an anticholinergic drug used as smooth muscle relaxant. It has both central and peripheral action. It is a competitive inhibitor of Acetylcholine. Valethamate blocks the muscarinic receptors and inhibits the action of Acetylcholine and produces muscle relaxations.
Pharmacokinets of Valethamate
Absorption: Valethamate is well absorbed after parenteral administration.
Distribution: It is widely distributed in the body .It crosses the placenta and excreted in breast milk.
Metabolism: It is metabolised in the liver.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Valethamate
20 - 30 minutes
Duration of Action for Valethamate
Half Life of Valethamate
4 hours
Side Effects of Valethamate
1. Dryness of mouth
2. Thirst
3. Vomiting
4. Mydriasis
5. Reduced bronchial secretions
6. Cycloplegia
7. Palpitations
8. Dryness of skin
9. Constipation
10. Urinary retention
11. Blurring of vision
Contra-indications of Valethamate
1. Hypersensitivity to Valethamate
2. Prostatic enlargement
3. Pyloric stenosis
4. Paralytic ileus
5. Ulcerative colitis
6. Toxic megacolon
7. Closed angle glaucoma
8. Myasthenia gravis
Special Precautions while taking Valethamate
1. Cardiac impairment-cardiac failure, cardiac insufficiency, cardiac surgery, Hypertension,
2. Thyrotoxicosis
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
NEONATES: Contraindicated
Indications for Valethamate
1. Cervical dilatation in the first stage of labour.
2. Symptomatic relief of gastrointestinal colic, Biliary colic, Ureteric colic
Interactions for Valethamate
Other antispsmodics, Some antihistamines, Phenothiazines, Disopyramide, Quinidine: Potentiate the effect of Valethamate,It delays gastric emptying and reduces absorption of other drugs
Typical Dosage for Valethamate
Oral: 10 - 20 mg 8 - 12 hours in a day.
Parenteral (IM or IV): 4 - 8 mg
Children: Not recommended
Schedule of Valethamate
Storage Requirements for Valethamate
Store at room temperature. Protect from light. Keep out of the reach of children
Effects of Missed Dosage of Valethamate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Valethamate
Give supportive measures and symptomatic treatment. To overcome the anticholinergic effect of Valethamate, Physostigmine 1 - 3mg IM or SC can be given repeat the dose if needed.

Home Delivery for Valethamate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including valethamate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for valethamate and other medicines and health products. Home delivery services for valethamate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take valethamate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for valethamate before they complete the sale. You can get this information while placing the order for valethamate with the pharmacy.

Valethamate is a generic medicine name and there are several brands available for it. Some of the brands for valethamate might be better known than valethamate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have valethamate in stock, you can ask for one of the branded alternatives for valethamate.