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- Pharmacology For Co Enzyme Q10 + Vitamin E
Co Enzyme Q10 + Vitamin E Pharmacology
Co Enzyme Q10 + Vitamin E
About Co Enzyme Q10 + Vitamin EN/AMechanism of Action of Co Enzyme Q10 + Vitamin EN/APharmacokinets of Co Enzyme Q10 + Vitamin EN/AOnset of Action for Co Enzyme Q10 + Vitamin EN/ADuration of Action for Co Enzyme Q10 + Vitamin EN/AHalf Life of Co Enzyme Q10 + Vitamin EN/ASide Effects of Co Enzyme Q10 + Vitamin EN/AContra-indications of Co Enzyme Q10 + Vitamin EN/ASpecial Precautions while taking Co Enzyme Q10 + Vitamin EN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Co Enzyme Q10 + Vitamin EAntioxidantInteractions for Co Enzyme Q10 + Vitamin EN/ATypical Dosage for Co Enzyme Q10 + Vitamin E1 capsule / daySchedule of Co Enzyme Q10 + Vitamin EN/AStorage Requirements for Co Enzyme Q10 + Vitamin EN/AEffects of Missed Dosage of Co Enzyme Q10 + Vitamin EN/AEffects of Overdose of Co Enzyme Q10 + Vitamin EN/ACo Enzyme Q10
About Co Enzyme Q101,4-benzoquinone derivative, oil-soluble vitamin-like substance, Enzyme cofactors, powerful antioxidantMechanism of Action of Co Enzyme Q10Coenzyme Q10 is vital for the proper transfer of electrons within the mitochondrial oxidative respiratory chain there it passes reducing equivalents to acceptors such as Coenzyme Q: cytochrome c - oxidoreductase:
CoQH2+ 2 FeIII-cytochrome c ? CoQ + 2 FeII-cytochrome c. main function of this transport is adenosine triphosphate production. Coenzyme Q10 also increases adenosine triphosphate levels by preventing the loss of the adenine nucleotide pool from cardiac cells. Coenzyme Q10 has activity as an antioxidant scavenger and an indirect stabilizer of calcium channels to decrease calcium overload. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Pharmacokinets of Co Enzyme Q10Absorption- Poorly absorbed after oral administration. Excretion- Excreted through bile and fecesOnset of Action for Co Enzyme Q10N/ADuration of Action for Co Enzyme Q10N/AHalf Life of Co Enzyme Q10N/ASide Effects of Co Enzyme Q101. Nausea
2. Vomiting
3. Stomach upset
4. Heartburn
5. Diarrhea
6. Loss of appetite
7. Skin itching
8. Rash
9. Insomnia
10. Headache
11. Dizziness
12. Irritability
13. Increased light sensitivity of the eyes
14. Fatigue
15. Flu-like symptoms
Contra-indications of Co Enzyme Q10N/ASpecial Precautions while taking Co Enzyme Q10N/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Co Enzyme Q101. Dietary supplement
2. Antioxidant
3. Migraine headaches
4. Parkinson`s Disease
5. Mitochondrial Encephalomyopathies
6. Migraine
7. CHF
8. Hypertension
9. Diabetes
10. Cancer
Interactions for Co Enzyme Q10N/ATypical Dosage for Co Enzyme Q10Adult-
Oral-
Mitochondrial cytopathies: 150 mg per day or 2 mg per kg per day with titration up to 3,000 mg per day in some patients
Parkinson`s disease: 300 to 1,200 mg per day in four divided doses
Cardiovascular problems: 50 to 200 mg per day
Migraine 100 to 200 mg per day
Schedule of Co Enzyme Q10N/AStorage Requirements for Co Enzyme Q10Keep tightly closed in a dry place. Do not expose to excessive heat.Effects of Missed Dosage of Co Enzyme Q10Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of Co Enzyme Q10Give supportive measures and symptomatic treatment.Vitamin E
About Vitamin EN/AMechanism of Action of Vitamin EVitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.Pharmacokinets of Vitamin EAbsorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin EN/ADuration of Action for Vitamin EN/AHalf Life of Vitamin EN/ASide Effects of Vitamin E1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence
Contra-indications of Vitamin E1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related InformationMay be usedOld Age Related InformationN/ABreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Vitamin E1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant
Interactions for Vitamin EOral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.
Typical Dosage for Vitamin EOral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.
Schedule of Vitamin EC1Storage Requirements for Vitamin EStore in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Vitamin ETake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin EProvide supportive measures and symptomatic treatment.Home Delivery for Co Enzyme Q10 + Vitamin E in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for co enzyme q10 + vitamin e and other medicines and health products. Home delivery services for co enzyme q10 + vitamin e may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Co Enzyme Q10 + Vitamin E is a generic medicine name and there are several brands available for it. Some of the brands for co enzyme q10 + vitamin e might be better known than co enzyme q10 + vitamin e itself. If the pharmacy that's willing to deliver medicines to your home doesn't have co enzyme q10 + vitamin e in stock, you can ask for one of the branded alternatives for co enzyme q10 + vitamin e.
