Isopropamide + Trifluoperazine Pharmacology
Isopropamide + Trifluoperazine
Isopropamide
2.Constipation
3.Blurred vision
4.Restlessness
5.Insomnia
6.Urinary hesitancy
7.Urine retention
8.Palpitation
9.Tachycardia
2.Obstructive gastro intestinal tract
3.Obstructive uropathy
4.Intestinal atony
5.Paralytic ileus
6.Pyloric stenosis
7.Prostatic hypertrophy
8.Toxic megacolon in ulcerative colitis
2.Hiatus hernia associated with reflux oesophagitis
3.Hyperthyroidism
4.Use caution while performing driving or performing other works requiring mental alertness.
2.Gastritis
3.Hyperchlorhydria
4.Irritable or spastic colon
Children: not recommended.
Trifluoperazine
Antiemetic activity: Antiemetic activity is by blocking dopamine receptor (D2 receptor) in the Chemoreceptor trigger zone (CTZ)
Distribution: It is distributed widely in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: It is excreted mainly through urine. Small amount of drug is excreted through faeces and breast milk.
2. Extrapyramidal reactions
3. Drowsiness
4. Sedation
5. Dizziness
6. Hypotension
7. Dry mouth
8. Constipation
9. Blurred vision
10. Agranulocytosis
11. Photosensitivity
12. Insomnia
13. Weight gain
14. Cholestatic jaundice
2. Comatose
3. Blood dyscrasias
4. Patient taking antidepressants
5. Liver damage
2. Hepatic impairment
3. Cardiovascular disease
4. Pheochromocytoma
5. Hypocalcaemia
6. Epilepsy
7. Cholestatic jaundice
8. Patient exposed to extreme heat or cold or phosphorus insecticides
9. Ceribrovascular disorder
10. Patient on ECT
11. Reaction to Insulin
12. Prostatic hyperplasia
13. Glaucoma
14. Peptic ulcer, slowly withdraw the drug with caution
2. Schizophrenia
3. Antiemetic
4. Anxiety
5. Behavioural disturbances
6. Mania
Almunium Salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after chlorpromazine.
Anticholinergics: Decrease efficacy and increase the anticholinergic side effects of chlorpromazine.
Barbiturates: Decreases efficacy.
Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension.
Bromocriptine: Efficacy decreased by chlorpromazine.
Charcoal: Prevents absorption of chlorpromazine.
Epinephrine, Norepinephrine: Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium: Disorientation, unconsciousness and extra-pyramidal symptoms.
Meperidine: Excessive sedation and hypotension.
TCAs: Serum concentration increased by chlorpromazine.
Valproic acid: Efficacy potentiated.
Propranolol: Increased plasma levels of both drugs.
MAOIs: Additive orthostatic hypotensive effect.
Lab. Tests: Pregnancy tests: False positive results.
Plasma bound iodine (PBI): Increase in PBI occurs.
Psychoses, Schizophrenia
Out patients: 2 - 4 mg / day in 2 divided doses. Dose can be increased depending on the severity of the disease.
Inpatients: 4 - 10 mg / day in 2 divided doses. Dose can be gradually increased up to 40 mg / day.
Antiemetic, Anxiety: 1 - 2 mg twice daily. Dose can be increased up to 6 mg / day in some case.
Children:
Psychoses, Schizophrenia: 1 - 2 mg / day. Dose can be gradually increased up to 15 mg / day.
Home Delivery for Isopropamide + Trifluoperazine in Your City
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Isopropamide + Trifluoperazine is a generic medicine name and there are several brands available for it. Some of the brands for isopropamide + trifluoperazine might be better known than isopropamide + trifluoperazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have isopropamide + trifluoperazine in stock, you can ask for one of the branded alternatives for isopropamide + trifluoperazine.
