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- Pharmacology For Chlorhexidine + Triclosan + Sodium monoflurophosphate
Chlorhexidine + Triclosan + Sodium monoflurophosphate Pharmacology
Chlorhexidine + Triclosan + Sodium monoflurophosphate
About Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AMechanism of Action of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/APharmacokinets of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AOnset of Action for Chlorhexidine + Triclosan + Sodium monoflurophosphateN/ADuration of Action for Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AHalf Life of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/ASide Effects of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AContra-indications of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/ASpecial Precautions while taking Chlorhexidine + Triclosan + Sodium monoflurophosphateN/APregnancy Related InformationContraindicated; since Clorhexedine is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Clorhexedine is contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Chlorhexidine + Triclosan + Sodium monoflurophosphateDental plaqueInteractions for Chlorhexidine + Triclosan + Sodium monoflurophosphateN/ATypical Dosage for Chlorhexidine + Triclosan + Sodium monoflurophosphateRinse the mouth with the solutionSchedule of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AStorage Requirements for Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AEffects of Missed Dosage of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AEffects of Overdose of Chlorhexidine + Triclosan + Sodium monoflurophosphateN/AChlorhexidine
About ChlorhexidineA bisbiguanide antimicrobial agent, Anti-infective, antiseptic.Mechanism of Action of ChlorhexidineThis drug has positive charge so it attach to the negative charge cell wall. This destabilizes and destroys the integrity and penetrates bacterial cell membranes. It results precipitation of the cytoplasm and interferes with membrane function by inhibiting oxygen utilization leading to a decrease in cellular ATP levels and cell death. In gram-negative bacteria, chlorhexidine affects the outer membrane allowing the release of periplasmic enzymes. The inner membrane of these organisms is not ruptured but the uptake of small molecules is impaired. At low concentrations chlorhexidine exhibits a bacteriostatic effect while at high concentrations it is bactericidal.Pharmacokinets of ChlorhexidineAbsorption- Poorly from the gastrointestinal tract.
Distribution- 87% bound to the plasma proteins.
Excretion- Excreted through feces.
Onset of Action for ChlorhexidineN/ADuration of Action for ChlorhexidineN/AHalf Life of ChlorhexidineN/ASide Effects of Chlorhexidine1. Bleeding
2. Tender
3. Enlarged gums
4. Cough
5. Congestion or tightness in chest
6. Wheezing
7. Staining of teeth
8. Calculus formation above the gum line
Contra-indications of Chlorhexidine1. Hypersensitivity to the drugSpecial Precautions while taking Chlorhexidine1. Avoid eating or drinking for at least 1 hour after each dose
2. To minimize the staining apply drug with the hollow cup brush tip of the Rota-dent perio tool to only the gum tissue, especially focus on the areas with pockets depths over 4mm
3. You may also alternate drug with custom bleaching trays at home
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Chlorhexidine1. Gingivitis
2. Acute and chronic otitis externa (ear infection/inflammation)
3. Periodontal disease
4. Superficial skin infections
5. Irrigation (cleansing) of wounds and as a medicated shampoo for the treatment of certain skin conditions (hot spots or acute moist dermatitis
Interactions for ChlorhexidineN/ATypical Dosage for ChlorhexidineOral rinse solutions - 0.1 percent.
Otic (ear) solutions - 1 percent.
Chlorhexidine solutions - 2 percent.
Chlorhexidine shampoo and conditioner 1 and 2 percent.
As an ear-cleansing agent - flush the ear canal once a day in cases of diagnosed otitis externa.
For skin conditions - clean the area twice daily.
For gingivitis - Chlorhexidine oral solution is applied as directed once a day. In the morning brush and floss for 2 minutes and than rinse with Chlorhexidine for 30 seconds.
Use 1/2 fl. oz. of undiluted. Swish in mouth for 30 seconds. After rinsing for 30 seconds be sure to spit out all the rinse, do NOT swallow any of the rinse. To minimize medicinal taste, DO NOT rinse with water immediately after use. In the evening brush and floss and rinse again for 30 seconds.
Chlorhexidine shampoo and conditioner - once or twice a week.
Pellet (extended-release), Periochip (in a biodegradable matrix of hydrolyzed gelatin cross-linked with glutaraldehyde), Cream, Dressing, Gel, Lotion, Ointment, Sponge forms are also available.
Schedule of ChlorhexidineN/AStorage Requirements for ChlorhexidineStore at room temperature below 77 degree F. Do not freeze.Effects of Missed Dosage of ChlorhexidineTake any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.Effects of Overdose of ChlorhexidineGive symptomatic and supportive treatment.Triclosan
About TriclosanA polychloro phenoxy phenol(chlorinated bisphenol), Antiseptic(antibacterial / antifungal agent),antiacne.Mechanism of Action of TriclosanTriclosan is a chlorinated bisphenol antiseptic.It is useful against Gram-positive and most Gram-negative bacteria but with poor activity against Pseudomonas species. It is also active against fungi. It is used in soaps, creams, and solutions in concentrations of up to 2% for disinfection of the hands and wounds and for disinfection of the skin prior to surgery, injections, or venepuncture. It is also used in oral hygiene products and in preparations for acne.Pharmacokinets of TriclosanN/AOnset of Action for TriclosanN/ADuration of Action for TriclosanN/AHalf Life of TriclosanN/ASide Effects of TriclosanAllergic skin reactionsContra-indications of TriclosanHypersensitivity to TriclosanSpecial Precautions while taking Triclosan1.Avoid contact with eyes
2.Avoid concomitant use of soap
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be used
Below 6 months:ContraindicatedIndications for TriclosanAntisepticInteractions for TriclosanN/ATypical Dosage for TriclosanTopical use:Wet area to be cleaned. Apply the medicament and wash for one minute. Rinse and repeat for 2 minutes. Dry thoroughly.Schedule of TriclosanN/AStorage Requirements for TriclosanStore at room temperature. Keep out of the reach of children. Protect from heat, light and moisture.Effects of Missed Dosage of TriclosanApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TriclosanGive supportive measures and symptomatic treatment.
Sodium monoflurophosphate
About Sodium monoflurophosphateA form of fluoride added to oral care products, Prophylatic in Dental caries.Mechanism of Action of Sodium monoflurophosphateSodium monofluorophosphate is used in the treatment of dental caries.It is used as additive for toothpaste containing fluorine.
Adequate incorporation of fluoride into teeth hardens the outer layers of enamel and increases resistances to demineralization. (The bacteria that cause caries produce acid through the fermentation of carbohydrates, which can dissolve the carbonated hydroxyapatite mineral of teeth, a process called demineralization).
Incorporation of fluoride into apatite crystals reduces the dissolution of apatite during acid attacks. Fluoride interacts with hydroxyapatite to form the less acid soluble fluorhydroxyapatite. Fluorhydroxyapatite is more resistant to dissolution by the acids produced by bacteria found in plaque. Fluoride may also promote the remineralization of enamel in early caries. Finally fluoride may reduce oral concentrations of cariogenic bacteria or reduce the metabolism of bacteria in plaque
Pharmacokinets of Sodium monoflurophosphateN/AOnset of Action for Sodium monoflurophosphateN/ADuration of Action for Sodium monoflurophosphateN/AHalf Life of Sodium monoflurophosphateN/ASide Effects of Sodium monoflurophosphateN/AContra-indications of Sodium monoflurophosphateN/ASpecial Precautions while taking Sodium monoflurophosphateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Sodium monoflurophosphate1.Dental cariesInteractions for Sodium monoflurophosphateN/ATypical Dosage for Sodium monoflurophosphateBrush with the paste 2 times daily or after each meal.Schedule of Sodium monoflurophosphateN/AStorage Requirements for Sodium monoflurophosphateN/AEffects of Missed Dosage of Sodium monoflurophosphateN/AEffects of Overdose of Sodium monoflurophosphateN/AHome Delivery for Chlorhexidine + Triclosan + Sodium monoflurophosphate in Your City
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