Iodine + Potassium iodide + Tannic Acid Pharmacology

Iodine + Potassium iodide + Tannic Acid

About Iodine + Potassium iodide + Tannic Acid
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Mechanism of Action of Iodine + Potassium iodide + Tannic Acid
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Pharmacokinets of Iodine + Potassium iodide + Tannic Acid
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Onset of Action for Iodine + Potassium iodide + Tannic Acid
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Duration of Action for Iodine + Potassium iodide + Tannic Acid
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Half Life of Iodine + Potassium iodide + Tannic Acid
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Side Effects of Iodine + Potassium iodide + Tannic Acid
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Contra-indications of Iodine + Potassium iodide + Tannic Acid
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Special Precautions while taking Iodine + Potassium iodide + Tannic Acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Iodine + Potassium iodide + Tannic Acid
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Interactions for Iodine + Potassium iodide + Tannic Acid
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Typical Dosage for Iodine + Potassium iodide + Tannic Acid
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Schedule of Iodine + Potassium iodide + Tannic Acid
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Storage Requirements for Iodine + Potassium iodide + Tannic Acid
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Effects of Missed Dosage of Iodine + Potassium iodide + Tannic Acid
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Effects of Overdose of Iodine + Potassium iodide + Tannic Acid
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Iodine

About Iodine
Essential trace element, fastest acting thyroid inhibitor, Antithyroid agent.
Mechanism of Action of Iodine
It is the fastest acting thyroid inhibitor which inhibits hormone release. It reduced to iodide response to both iodine and iodides are identical. Endocytosis of colloid and proteolysis of thyroglobulin comes to a halt. It has a direct action on thyroid cells and also attenuate TSH and cyclic AMP induced thyroid stimulation. Excess iodide inhibits it`s on transport in thyroid cells and alter the redox potential of cells; thus interfering with iodination and reduces T3 or T4 synthesis. The gland if enlarged; shrinks, becomes firm and less vascular. The thyroid status returns to normal at a faster rate.
Pharmacokinets of Iodine
Absorption: Well absorbed orally.
Distribution: Widely distributed in the body and also crosses the placenta.
Onset of Action for Iodine
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Duration of Action for Iodine
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Half Life of Iodine
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Side Effects of Iodine
1. Fever
2. Angioedema
3. Swelling of lips and eyelids
4. Arthralgia
5. Thrombocytopenia
6. Salivation
7. Sneezing
8. Lymphadenopathy
9. Petechial haemorrhage.
10. Burning sensation in mouth
11. Headache
12. Rashes
13. Flaring of acne
Contra-indications of Iodine
1. Hypersensitivity to the drug
Special Precautions while taking Iodine
1. Long term therapy with high dose
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Iodine
1. Hyperthyroidism
2. Hypothyroidism
3. Prior to thyroidectomy
4. Prophylaxis of endemic goiter
Interactions for Iodine
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Typical Dosage for Iodine
Oral: 5 to 10ml in water 8th hourly.
Schedule of Iodine
H
Storage Requirements for Iodine
Store in a well closed container and protects from light.
Effects of Missed Dosage of Iodine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Iodine
Provide symptomatic treatment and supportive measures.

Potassium Iodide

About Potassium Iodide
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Mechanism of Action of Potassium Iodide
It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.
Pharmacokinets of Potassium Iodide
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Onset of Action for Potassium Iodide
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Duration of Action for Potassium Iodide
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Half Life of Potassium Iodide
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Side Effects of Potassium Iodide
1.Nausea
2.Vomiting
3.Upset stomach, or stomach pain
4.Mild skin rash
5.A metallic taste in the mouth.
Contra-indications of Potassium Iodide
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Special Precautions while taking Potassium Iodide
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Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Potassium Iodide
1.Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.
2.To protect the thyroid gland from radiation injury before and following administration of radioactive iodide (e.g., for diagnostic purposes) and in radiation emergencies (e.g., accidental exposure to radiation).
3.Chronic respiratory problems such as asthma, chronic bronchitis, and emphysema(expectorant).
4.Component of some eye drops.
5.Antifungal: Cutaneous Sporotrichosis is a fungus that can cause lesions on the skin. A saturated solution of potassium iodide can be used to treat the lesion.

Interactions for Potassium Iodide
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Typical Dosage for Potassium Iodide
Usual Adult Dose for Cough:300 to 650 mg orally 3 to 4 times a day.
Usual Adult Dose for Hyperthyroidism:
Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.

Usual Adult Dose for Cutaneous Sporotrichosis:250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 2 to 2.5 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.
Usual Adult Dose for Radiation Emergency:
Pregnant or lactating women with exposure >= 5 centigrays (cGy): 130 mg orally per day.
>18 and <=40 years with exposure >= 10 centigrays (cGy): 130 mg orally per day.
>40 years with exposure >= 500 centigrays (cGy): 130 mg orally per day.
Usual Pediatric Dose for Cough:60 to 250 mg orally every 4 to 6 times a day.
Usual Pediatric Dose for Hyperthyroidism:Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.
Usual Pediatric Dose for Cutaneous Sporotrichosis:250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 1.25 to 2 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.
Usual Pediatric Dose for Radiation Emergency:
<=1 month with exposure >= 5 centigrays (cGy): 16 mg orally per day.
>1 month <=3 years with exposure >= 5 centigrays (cGy): 32 mg orally per day.
>3 years <= 18 years (less than 70 kg) with exposure >= 5 centigrays (cGy): 65 mg orally per day.
>13 years >= 70 kg with exposure >= 5 centigrays (cGy): 130 mg orally per day.

Schedule of Potassium Iodide
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Storage Requirements for Potassium Iodide
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Effects of Missed Dosage of Potassium Iodide
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Effects of Overdose of Potassium Iodide
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Tannic acid

About Tannic acid
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Mechanism of Action of Tannic acid
Tannic acid has anti-bacterial, anti-enzymatic and astringent properties. The anti-oxidant and anti-mutagenic properties of tannic acid are beneficial. Tannic Acid is used in dental preparation due to its astringent action. It helps in shrinking the swollen mucosa and heals ulcer faster.
Pharmacokinets of Tannic acid
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Onset of Action for Tannic acid
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Duration of Action for Tannic acid
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Half Life of Tannic acid
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Side Effects of Tannic acid
Mild tingling sensation
Contra-indications of Tannic acid
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Special Precautions while taking Tannic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tannic acid
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Interactions for Tannic acid
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Typical Dosage for Tannic acid
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Schedule of Tannic acid
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Storage Requirements for Tannic acid
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Effects of Missed Dosage of Tannic acid
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Effects of Overdose of Tannic acid
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