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- Pharmacology For Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone Pharmacology
Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
About Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AMechanism of Action of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/APharmacokinets of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AOnset of Action for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ADuration of Action for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AHalf Life of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ASide Effects of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AContra-indications of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ASpecial Precautions while taking Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AInteractions for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ATypical Dosage for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ASchedule of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AStorage Requirements for Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AEffects of Missed Dosage of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/AEffects of Overdose of Dicyclomine + Clidinium bromide + Paracetamol + DimethiconeN/ADicyclomine
About DicyclomineAnticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.Mechanism of Action of DicyclomineDicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.Pharmacokinets of DicyclomineAbsorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine1-2 hours.Duration of Action for Dicyclomine4-6 hours.Half Life of Dicyclomine1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))Side Effects of Dicyclomine1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Dicyclomine1. Irritable bowel syndrome
2.Colicky pain
Interactions for DicyclomineN/ATypical Dosage for DicyclomineAdult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of DicyclomineHStorage Requirements for DicyclomineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of DicyclomineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DicyclomineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.Clidinium Bromide
About Clidinium BromideIt is a quaternary ammonium compound with anticholingeric properties, Antispasmodics (Systemic).Mechanism of Action of Clidinium BromideClidinium bromide is an anticholinergic drug. It exerts its action by inhibiting muscarinic cholinergic receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.Pharmacokinets of Clidinium BromideAbsorption: Clidinium bromide is poorly absorbed about (10 - 25 %) after oral administration.
Distribution:It does not penetrate CNS and eye.
Metabolism: It is extensively metabolised in the small intestine (by hydrolysis) and in the liver to inactive metabolites.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Clidinium Bromide60 minuteDuration of Action for Clidinium Bromide3 hoursHalf Life of Clidinium BromideN/ASide Effects of Clidinium Bromide1.Dry mouth
2.Nausea
3.Vomiting
4.Constipation
5.Muscle weakness
6.Blurred vision
7.Drowsines
Contra-indications of Clidinium Bromide1.Hypersensitivity to Clidinium bromide and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Bladder neck obstruction
5.Prostatic hypertrophy
Special Precautions while taking Clidinium Bromide1.Renal impairment
2.Hepatic impairment
3.Cardiovascular diseases- Hypertension
4.Use caution while performing driving or performing other works requiring mental alertness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicated
Indications for Clidinium Bromide1.Peptic ulcer
2.Gastritis
3.Irritable bowel syndrome
4.Nervous dyspepsia
Interactions for Clidinium BromideAmantadine : Increase in anticholingeric side effects.
Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced .
Phenothiazines : Decreases antipsychotic activity, and increases anticholingeric activity.
TCAs: Increased anticholinergic side effects ( Dry mouth, constipation, urinary retention)Typical Dosage for Clidinium BromideAdult: 2.5 - 5 mg 3 - 4 times daily before meals and at bed time.
Children: not recommended.
Schedule of Clidinium BromideHStorage Requirements for Clidinium BromideStore at below 30 degree C in a tightly closed container. Protect from moisture and sunlight.
Keep out of the reach of children
Effects of Missed Dosage of Clidinium BromideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clidinium BromideGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Dimethicone
About DimethiconeOral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.Mechanism of Action of DimethiconeActivated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of DimethiconeN/AOnset of Action for DimethiconeN/ADuration of Action for DimethiconeN/AHalf Life of DimethiconeN/ASide Effects of DimethiconeN/AContra-indications of DimethiconeHypersensitivity to Dimethicone activatedSpecial Precautions while taking DimethiconeKidney failurePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dimethicone1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for DimethiconeN/ATypical Dosage for Dimethicone125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of DimethiconeN/AStorage Requirements for DimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of DimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DimethiconeGive symptomatic and supportive treatment.Home Delivery for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone in Your City
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Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone is a generic medicine name and there are several brands available for it. Some of the brands for dicyclomine + clidinium bromide + paracetamol + dimethicone might be better known than dicyclomine + clidinium bromide + paracetamol + dimethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + clidinium bromide + paracetamol + dimethicone in stock, you can ask for one of the branded alternatives for dicyclomine + clidinium bromide + paracetamol + dimethicone.
