Orlistat Pharmacology


About Orlistat
Anti-obese drug. Saturated derivative of lipstatin.
Mechanism of Action of Orlistat
Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake.Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead.
Pharmacokinets of Orlistat
Bioavailability :- Negligible
Protein binding :- >99%
Metabolism :- In the GI tract
Half life :- 1 to 2 hours
Excretion :- Fecal
Onset of Action for Orlistat
Duration of Action for Orlistat
Half Life of Orlistat
Side Effects of Orlistat
The primary side effects of the drug are gastrointestinal-related,
1.Steatorrhea (oily, loose stools with excessive flatus due to unabsorbed fats reaching the large intestine),.
2. Fecal incontinence and frequent or urgent bowel movements.

Long Term Includes:-

1.Breast Cancer
2.Colon Cancer
Contra-indications of Orlistat
2.Hypersensitivity to orlistat
3.Reduced gallbladder function (e.g. after cholecystectomy)
4.Pregnancy and breastfeeding
5.Use caution with: obstructed bile duct, impaired liver function, and pancreatic disease
Special Precautions while taking Orlistat
Absorption of fat-soluble vitamins and other fat-soluble nutrients is inhibited by the use of orlistat. A multivitamin tablet containing vitamins A, D, E, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat.
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Orlistat
1.Anti obese drug.
2.To reduce Blood pressure moderately
3.To delay the onset of type 2 diabetes mellitus.
Interactions for Orlistat
1.Orlistat may reduce plasma levels of ciclosporin (also known as "cyclosporin" or "cyclosporine", trade names Sandimmune, Gengraf, Neoral, etc.), an immunosuppressive drug frequently used to prevent transplant rejection; the two drugs should therefore not be administered concomitantly.
2. Orlistat can also impair absorption of the antiarrhythmic amiodarone.
Typical Dosage for Orlistat
120 mg three times daily before meals.
Schedule of Orlistat
Storage Requirements for Orlistat
Effects of Missed Dosage of Orlistat
Effects of Overdose of Orlistat

Home Delivery for Orlistat in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including orlistat.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for orlistat and other medicines and health products. Home delivery services for orlistat may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take orlistat only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for orlistat before they complete the sale. You can get this information while placing the order for orlistat with the pharmacy.

Orlistat is a generic medicine name and there are several brands available for it. Some of the brands for orlistat might be better known than orlistat itself. If the pharmacy that's willing to deliver medicines to your home doesn't have orlistat in stock, you can ask for one of the branded alternatives for orlistat.