Cefixime + Clavulanic acid Pharmacology

Cefixime + Clavulanic acid

About Cefixime + Clavulanic acid
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Mechanism of Action of Cefixime + Clavulanic acid
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Pharmacokinets of Cefixime + Clavulanic acid
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Onset of Action for Cefixime + Clavulanic acid
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Duration of Action for Cefixime + Clavulanic acid
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Half Life of Cefixime + Clavulanic acid
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Side Effects of Cefixime + Clavulanic acid
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Contra-indications of Cefixime + Clavulanic acid
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Special Precautions while taking Cefixime + Clavulanic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Cefixime + Clavulanic acid
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Interactions for Cefixime + Clavulanic acid
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Typical Dosage for Cefixime + Clavulanic acid
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Schedule of Cefixime + Clavulanic acid
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Storage Requirements for Cefixime + Clavulanic acid
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Effects of Missed Dosage of Cefixime + Clavulanic acid
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Effects of Overdose of Cefixime + Clavulanic acid
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Cefixime

About Cefixime
Third Generation Cephalosporin Oral antibiotic
Mechanism of Action of Cefixime
Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.
Pharmacokinets of Cefixime
Absorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urine
Onset of Action for Cefixime
Within one hour
Duration of Action for Cefixime
18 hours
Half Life of Cefixime
3 hour
Side Effects of Cefixime
1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime
1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime
1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Above 6 months: may be used
Neonates: contraindicated
Indications for Cefixime
1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for Cefixime
Probenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.
Typical Dosage for Cefixime
Adults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of Cefixime
H
Storage Requirements for Cefixime
N/A
Effects of Missed Dosage of Cefixime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefixime
Adopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis

Clavulanic acid

About Clavulanic acid
Beta-Lactamase Inhibitor, Antibiotic resistance reducer to penicillin group.
Mechanism of Action of Clavulanic acid
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Pharmacokinets of Clavulanic acid
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Onset of Action for Clavulanic acid
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Duration of Action for Clavulanic acid
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Half Life of Clavulanic acid
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Side Effects of Clavulanic acid
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Contra-indications of Clavulanic acid
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Special Precautions while taking Clavulanic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Clavulanic acid
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Interactions for Clavulanic acid
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Typical Dosage for Clavulanic acid
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Schedule of Clavulanic acid
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Storage Requirements for Clavulanic acid
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Effects of Missed Dosage of Clavulanic acid
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Effects of Overdose of Clavulanic acid
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Home Delivery for Cefixime + Clavulanic acid in Your City

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Cefixime + Clavulanic acid is a generic medicine name and there are several brands available for it. Some of the brands for cefixime + clavulanic acid might be better known than cefixime + clavulanic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefixime + clavulanic acid in stock, you can ask for one of the branded alternatives for cefixime + clavulanic acid.