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- Pharmacology For Olmesartan + Hydrochlorothiazide
Olmesartan + Hydrochlorothiazide Pharmacology
Olmesartan + Hydrochlorothiazide
About Olmesartan + HydrochlorothiazideN/AMechanism of Action of Olmesartan + HydrochlorothiazideN/APharmacokinets of Olmesartan + HydrochlorothiazideN/AOnset of Action for Olmesartan + HydrochlorothiazideN/ADuration of Action for Olmesartan + HydrochlorothiazideN/AHalf Life of Olmesartan + HydrochlorothiazideN/ASide Effects of Olmesartan + HydrochlorothiazideN/AContra-indications of Olmesartan + HydrochlorothiazideN/ASpecial Precautions while taking Olmesartan + HydrochlorothiazideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Olmesartan + HydrochlorothiazideN/AInteractions for Olmesartan + HydrochlorothiazideN/ATypical Dosage for Olmesartan + HydrochlorothiazideN/ASchedule of Olmesartan + HydrochlorothiazideN/AStorage Requirements for Olmesartan + HydrochlorothiazideN/AEffects of Missed Dosage of Olmesartan + HydrochlorothiazideN/AEffects of Overdose of Olmesartan + HydrochlorothiazideN/AOlmesartan
About OlmesartanAn angiotensin II receptor antagonist, Imidazole derivative, Antihypertensive.Mechanism of Action of OlmesartanOlmesartan is a competitive antagonist of angiotensin-II at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-II such as: - Vasoconstriction, Central & Peripheral sympathetic stimulus, Release of aldosterone and adrenaline, Salt and water reabsorption and Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels and at last produces lowering of blood pressure.Pharmacokinets of OlmesartanAbsorption: It is rapidly and completely absorbed after oral administration.
Metabolism: It undergoes metabolism in the liver.
Excretion: It is excreted primarily in urine and small amount in urine.
Onset of Action for OlmesartanN/ADuration of Action for OlmesartanN/AHalf Life of Olmesartan13 hoursSide Effects of Olmesartan1.Dizziness
2.Headache
3.Diarrhea
4.Upper respiratory tract infection
5.Abnormal heart rate
6.Chest pain
7.Peripheral edema
8.Vertigo
9.Abdominal pain
10.Dyspepsia
11.Nausea
12.Hypercholesterolemia
13.Hyperuricemia
14.Arthralgia
15.Arthritis
16.Myalgia
17.Rash
18.Facial edema
Contra-indications of OlmesartanHypersensitivity to OlmesartanSpecial Precautions while taking Olmesartan1.Renal impairment
2.Renal artery stenosis
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for OlmesartanHypertensionInteractions for OlmesartanN/ATypical Dosage for OlmesartanAdult: 20mg/day and if needed dose can be increased to 40mg/daySchedule of OlmesartanN/AStorage Requirements for OlmesartanStore at 20 - 25 degree C. Keep out of the reach of children. Keep away from heat, light and moisture.Effects of Missed Dosage of OlmesartanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OlmesartanGive supportive measures and symptomatic treatment.Hydrochlorothiazide
About HydrochlorothiazideThiazide derivatibve, Diuretic.Mechanism of Action of HydrochlorothiazideIt is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It has additional carbonic anhydrase inhibitory actions in proximal tubules. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Vertigo: Diuretics are used in vertigo in assumption that vertigo is due to endolymphatic hydrops. They reduce labyrinthine fluid pressure
Pharmacokinets of HydrochlorothiazideAbsorption: It is absorbed after oral administration.
Metabolism: It is not metabolized in the body.
Excretion: Excreted unchanged in urine.
Onset of Action for Hydrochlorothiazide1 to 3 hoursDuration of Action for Hydrochlorothiazide12 to 16 hoursHalf Life of Hydrochlorothiazide5 to 15 hoursSide Effects of Hydrochlorothiazide1. Dizziness
2. Blurred vision
3. Confusion
4. Tingling fingers
5. Dry mouth
6. Nausea
7. Diarrhoea
8. Constipation
9. Vomiting
10. Weakness
11. Hypokalaemia
12. Hyponatraemia
13. Hyperuricaemia
14. Elevated levels of glucose, calcium and lipids
15. Gastro intestinal disturbances
16. Polyuria
17. Electrolyte imbalance
18. Jaundice
19. Rashes
20. Photosensitivity
21. Fever
22. Itching
23. Myalgia
24. Muscle cramps
25. Arthralgia
26. Blood dyscrasias
27. Ototoxicity
Contra-indications of Hydrochlorothiazide1. Hyper uricaemia
2. Hyper calcaemia
3. Renal impairment
4. Hepatic impairment
5. Anuria
6. Hypersensitivity to the drug
7. Hyper sensitivity to sulfonamides
8. Fluid and electrolyte imbalance
Special Precautions while taking Hydrochlorothiazide1. Gout
2. Diabetes mellitus
3. Renal impairment
4. Hepatic impairment
5. Monitor and correct Fluid and electrolyte imbalance
6. Hyper parathyroidism
7. Cirrhosis
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Hydrochlorothiazide1. Hypertension
2. Oedema associated with heart failure
3. Oedema due to renal and hepatic diseases
4. Diabetes insipidus
5. Idiopathic hypercalciurea.
6. Vertigo
Interactions for HydrochlorothiazideCholestyramine & Colestipol: decrease absorption of hydrochlorothiazide.
Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity.
Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy.
Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of hydrochlorothiazide increased.
Metoclopramide: Bioavailability of hydrochlorothiazide decreased.
NSAIDs: Natriuretic effect of hydrochlorothiazide decreased.
Typical Dosage for HydrochlorothiazideAdults:
Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response.
Children: 1mg/kg single daily dose.
Oedema:
Adults:
Starts with 25 to 50mg. Increased the dose until desired response is obtained.
Maximum dose: 200mg/day
Maintenance dosage: 25 to 100mg daily or on alternate days.
Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses
Schedule of HydrochlorothiazideGStorage Requirements for HydrochlorothiazideStore at room temperature in a well closed container and protected from light.Effects of Missed Dosage of HydrochlorothiazideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of HydrochlorothiazideTreatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.Home Delivery for Olmesartan + Hydrochlorothiazide in Your City
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Olmesartan + Hydrochlorothiazide is a generic medicine name and there are several brands available for it. Some of the brands for olmesartan + hydrochlorothiazide might be better known than olmesartan + hydrochlorothiazide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have olmesartan + hydrochlorothiazide in stock, you can ask for one of the branded alternatives for olmesartan + hydrochlorothiazide.
