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- Pharmacology For Montelukast + Levocetirizine
Montelukast + Levocetirizine Pharmacology
Montelukast + Levocetirizine
About Montelukast + LevocetirizineN/AMechanism of Action of Montelukast + LevocetirizineN/APharmacokinets of Montelukast + LevocetirizineN/AOnset of Action for Montelukast + LevocetirizineN/ADuration of Action for Montelukast + LevocetirizineN/AHalf Life of Montelukast + LevocetirizineN/ASide Effects of Montelukast + LevocetirizineN/AContra-indications of Montelukast + LevocetirizineN/ASpecial Precautions while taking Montelukast + LevocetirizineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Montelukast + LevocetirizineN/AInteractions for Montelukast + LevocetirizineN/ATypical Dosage for Montelukast + LevocetirizineN/ASchedule of Montelukast + LevocetirizineN/AStorage Requirements for Montelukast + LevocetirizineN/AEffects of Missed Dosage of Montelukast + LevocetirizineN/AEffects of Overdose of Montelukast + LevocetirizineN/AMontelukast
About MontelukastLeukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.Mechanism of Action of MontelukastMontelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of MontelukastAbsorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.
Onset of Action for MontelukastN/ADuration of Action for MontelukastN/AHalf Life of Montelukast2.75 - 5.5 hoursSide Effects of Montelukast1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast1.Hypersensitivity to Montelukast
2.Acute asthmatic attacksSpecial Precautions while taking MontelukastN/APregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for MontelukastAsthma.Interactions for MontelukastBarbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for MontelukastAdult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time
Schedule of MontelukastN/AStorage Requirements for MontelukastStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of MontelukastTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MontelukastGive supportive measures and symptomatic treatmentLevocetirizine
About LevocetirizineA third-generation non-sedative H1 antagonist, Antihistamine.Mechanism of Action of LevocetirizineThis active enantiomer of cetrizine is a potent, nonsedative and selective H1 receptor antagonist. It antagonizes the allergic symptoms produced by histamines like runny nose, cold, cough etc. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of LevocetirizineAbsorption- Well absorbed after oral administration.
Distribution-Widely distributed in the body.90% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted via urine and feces.
Onset of Action for LevocetirizineN/ADuration of Action for LevocetirizineN/AHalf Life of LevocetirizineIts plasma half life is 6-10hrsSide Effects of Levocetirizine1. Headache
2. Abdominal pain
3. Dry mouth
4. Fatigue
5. Pharyngitis
6. Sleepiness
7. Asthenia
8. Rhinitis causing a blocked or runny nose
9. Migraine
Contra-indications of Levocetirizine1. Allergy to drug or other medicines that contain piperazine derivatives
2. Hereditary galactose intolerance
3. Hereditary Lapp lactase deficiency
4. Inherited glucose-galactose malabsorption
5. Severely decreased kidney function
Special Precautions while taking Levocetirizine1. Decreased kidney function
2. Avoid alcohol or any work which require mental alertness like driving and machine operation during treatment.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Levocetirizine1. Rhinitis (seasonal and perennial)
2. Idiopathic urticaria
Interactions for LevocetirizineCoadministration with alcohol or other CNS depressants may have additional CNS depressant effect. Typical Dosage for LevocetirizineOral-
Adult-5mg/day.
Children (>6yrs) - 5mg/day. Schedule of LevocetirizineN/AStorage Requirements for LevocetirizineStore in a cool, dry place, away from direct light and heat.
Keep out of reach of children.
Effects of Missed Dosage of LevocetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of LevocetirizineGive symptomatic and supportive treatment.Home Delivery for Montelukast + Levocetirizine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including montelukast + levocetirizine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for montelukast + levocetirizine and other medicines and health products. Home delivery services for montelukast + levocetirizine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take montelukast + levocetirizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for montelukast + levocetirizine before they complete the sale. You can get this information while placing the order for montelukast + levocetirizine with the pharmacy.
Montelukast + Levocetirizine is a generic medicine name and there are several brands available for it. Some of the brands for montelukast + levocetirizine might be better known than montelukast + levocetirizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have montelukast + levocetirizine in stock, you can ask for one of the branded alternatives for montelukast + levocetirizine.
