Drospirenone Pharmacology

Drospirenone

About Drospirenone
Synthetic progestin,In combined oral contraceptive.
Mechanism of Action of Drospirenone
Drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
Pharmacokinets of Drospirenone
Absoption: Drospirenone absorbed after oral administration
Distribution: 97% bound to serum protein
Metabolism:Metabolised in the liver
Excretion: Excreted in urine and feces
Onset of Action for Drospirenone
N/A
Duration of Action for Drospirenone
N/A
Half Life of Drospirenone
30 hours
Side Effects of Drospirenone
Upper respiratory infections
1.Abdominal pain
2.Headache and spotting of menstrual blood
3.Back pain
4.Venous thromboembolism
5.Nausea
6.Vomiting
7.Weight gain
Contra-indications of Drospirenone
1.Hyper sensitivity to drug
2.Thrombo embolic disorder
3.Breast cancer
4.Hepatic impairment
Special Precautions while taking Drospirenone
1.May increase risk of breast cancer
2.Thromboembolism and glucose intolerance
3.Renal impairment
4.Hepatic problem
5.Migrain
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Drospirenone
1.Oral contraceptive,
2.Hormone replacement
Interactions for Drospirenone
ACE inhibitors/Angiotensin receptor blockers, Pottasimsparing diuretics: cause hyperkalemiaRifampicin: Reduce efficacy of drug
Typical Dosage for Drospirenone
20 ?g ethinylestradiol and 3 mg drospirenone administered daily for 24 days followed by a 4-day hormone-free interval.
Schedule of Drospirenone
N/A
Storage Requirements for Drospirenone
Store in a well closed container at controlled room temperature bellow 25 degree C in a dry dark place. Keep out of reach of children.
Effects of Missed Dosage of Drospirenone
N/A
Effects of Overdose of Drospirenone
N/A

Home Delivery for Drospirenone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including drospirenone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drospirenone and other medicines and health products. Home delivery services for drospirenone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take drospirenone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drospirenone before they complete the sale. You can get this information while placing the order for drospirenone with the pharmacy.

Drospirenone is a generic medicine name and there are several brands available for it. Some of the brands for drospirenone might be better known than drospirenone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drospirenone in stock, you can ask for one of the branded alternatives for drospirenone.