Ibandronic acid Pharmacology

Ibandronic acid

About Ibandronic acid
Bisphosphonate derivative, Bone resorption inhibitor.
Mechanism of Action of Ibandronic acid
Inhibition of the enzyme farnesyl pyrophosphate synthase. Subsequently, the prenylation of GTP-binding proteins, Ibandronic acid is a potent bone resorption inhibitor, which acts on osteoclasts or on osteoclast precursors. It increases bone mineral density by reducing the rate of bone resorption.
Pharmacokinets of Ibandronic acid
Absorption: Poorly absorbed orally. Absolute bioavailability: <1%.
Distribution: Poorly absorbed orally.
Metabolism: Does not undergo metabolism
Excretion: Via urine. Unabsorbed drug via faeces.
Onset of Action for Ibandronic acid
Duration of Action for Ibandronic acid
Half Life of Ibandronic acid
10 to 60 hours
Side Effects of Ibandronic acid
1.Electrolyte disturbances
2.GI disturbances
3.Musculoskeletal pain
6.Renal impairment (parenteral)
Contra-indications of Ibandronic acid
1.Severe renal impairment,
2.Uncorrected hypocalcaemia,
3.Acute upper GI inflammation,
4.Inability to stand or sit upright for at least 60 min (oral).

Special Precautions while taking Ibandronic acid
History of bone/joint/muscle pain
GI Disturbunce
Risk factors for osteonecrosis of the jaw
Pregnancy and lactation.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Ibandronic acid
Hypercalcaemia of malignancy
Interactions for Ibandronic acid
Impaired absorption with aluminium, calcium, iron, magnesium compounds.
Increased risk of GI or renal adverse effects with NSAIDs.
Additive hypocalcaemic effects with aminoglycosides.
Typical Dosage for Ibandronic acid
Prophylaxis of skeletal events in patients with breast cancer and bone metastases
Adult: As ibandronic acid: 50 mg daily.
Postmenopausal osteoporosis
Adult: As ibandronic acid: 150 mg once mthly on the same date each mth or 2.5 mg daily
Hypercalcaemia of malignancy
Adult: As ibandronic acid: 2-4 mg as a single dose infused over 2 hr. Max: 6 mg/dose.
Postmenopausal osteoporosis
Adult: As ibandronic acid: 3 mg once every 3 mth; inj given over 15-30 sec.Intravenous
Prophylaxis of skeletal events in patients with breast cancer and bone metastases
Adult: As ibandronic acid: 6 mg infused over at least 15 minutes. Repeat dose every 3-4 wk.
Schedule of Ibandronic acid
Storage Requirements for Ibandronic acid
Oral: Store at controlled room temperature of 15-30?C (59-86?F).
Intravenous: Store at controlled room temperature of 15-30?C (59-86?F).
Keep out of the reach of children.
Effects of Missed Dosage of Ibandronic acid
Effects of Overdose of Ibandronic acid

Home Delivery for Ibandronic acid in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ibandronic acid and other medicines and health products. Home delivery services for ibandronic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ibandronic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ibandronic acid before they complete the sale. You can get this information while placing the order for ibandronic acid with the pharmacy.

Ibandronic acid is a generic medicine name and there are several brands available for it. Some of the brands for ibandronic acid might be better known than ibandronic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ibandronic acid in stock, you can ask for one of the branded alternatives for ibandronic acid.