Distribution: Protein binding 95%
Metabolism: Metabolised in the liver
Excretion: Excretion via fecal(68%), and renal(13%)
2.Lymphoblastic leukemia (PH+ALL)
3.Gastrointestinal stromal tumors
CYP3A4 inducers (dexamethasone, phenytoin, carbamazepine, rifampicin, phenobarbital or St. John?s Wort)----- increase metabolism---- decrease Imatinib exposure (74%)
CYP2D6 inhibitors (e.g. doxorubicin, quinidine, vinca alkaloids, dextropropoxyphene)---- decrease metabolism---- increased Imatinib concentrations.
CYP 2C9 substrates (e.g. Warfarin)---- Imatinib inhibits CYP2C9 at high doses---- increase anticoagulant effect.
600 mg to 800 mg (given as 400 mg twice daily) ( in accelerated phase or blast crisis Ph+CML)
Children:340 mg/m?/day (not to exceed 600 mg) in Ph+ CML
Home Delivery for Imatinib in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including imatinib.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for imatinib and other medicines and health products. Home delivery services for imatinib may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take imatinib only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for imatinib before they complete the sale. You can get this information while placing the order for imatinib with the pharmacy.
Imatinib is a generic medicine name and there are several brands available for it. Some of the brands for imatinib might be better known than imatinib itself. If the pharmacy that's willing to deliver medicines to your home doesn't have imatinib in stock, you can ask for one of the branded alternatives for imatinib.