Acamprosate Pharmacology

Acamprosate

About Acamprosate
Sulfonic Acids and Derivatives, for management of chronic alcoholism (drug depenance) and maintain balance.
Mechanism of Action of Acamprosate
Acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores the balance. It seems to inhibit NMDA receptors while activating GABA receptors. (Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition).
Pharmacokinets of Acamprosate
Absorptiom: Absorbed after oral administration
Distribution: Volume of distribution estimated to be 72 to 109 L (1 L/kg). Protein binding is negligible.
Metabolism: Acamprosate does not undergo metabolism.
Excretion: Major route of excretion is via kidneys.
Onset of Action for Acamprosate
N/A
Duration of Action for Acamprosate
N/A
Half Life of Acamprosate
20 - 33 hours
Side Effects of Acamprosate
1.Nausea
2.Vomiting
3.Abdominal pain
4.Hypertension
5.Cough
6.Headaches
7.Insomnia
8.Impotence
Contra-indications of Acamprosate
Hypersensitivity to drug.
Severe renal impairment.
Special Precautions while taking Acamprosate
1.Mild to moderate renal impairment
2.Suicidal ideation or behavior
3.Elderly patients
4.Breastfeeding patients
5.Children.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Acamprosate
To maintain abstinence from alcohol in patients with alcohol dependence who are abstinent when treatment begins.
Interactions for Acamprosate
Antidepressants : Weight gain and loss reported more frequently compared with either agent alone.
Naltrexone: Acamprosate levels may be increased; however, no dosage adjustment is recommended.
Typical Dosage for Acamprosate
Adults: PO Two 333 mg tablets 3 times daily.
Schedule of Acamprosate
N/A
Storage Requirements for Acamprosate
Store tablets at controlled room temperature (59? to 86?F). Keep out of the reach of children.
Effects of Missed Dosage of Acamprosate
N/A
Effects of Overdose of Acamprosate
N/A

Home Delivery for Acamprosate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including acamprosate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for acamprosate and other medicines and health products. Home delivery services for acamprosate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take acamprosate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for acamprosate before they complete the sale. You can get this information while placing the order for acamprosate with the pharmacy.

Acamprosate is a generic medicine name and there are several brands available for it. Some of the brands for acamprosate might be better known than acamprosate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have acamprosate in stock, you can ask for one of the branded alternatives for acamprosate.