Bivalirudin Pharmacology


About Bivalirudin
Anticoagulant,Thrombin inhibitor.
Mechanism of Action of Bivalirudin
Inhibits the action of thrombin by binding both to its catalytic site and to its anion-binding exosite of circulating and clot-bound thrombin.
Pharmacokinets of Bivalirudin
Absorption: It is not absorbed orally; Should be given parenterally.
Dstribution: drug distribution is limited to the intravascular compartment. Bivalirudin does not bind to plasma proteins, other than thrombin, or to red blood cells.
Metabolism: Metabolism of bivalirudin occurs in the liver or by other sites by means of proteolysis.
Excretion: Excreted as fragments in urine.
Onset of Action for Bivalirudin
2 minutes
Duration of Action for Bivalirudin
40 minutes after infusion
Half Life of Bivalirudin
25 ? 210 minutes
Side Effects of Bivalirudin
2.Hypersensitivity reactions
3.Cardiac problem
8.Inj site pain and Anxiety
9.Potentially Fatal: Severe anaphylactic reactions which may lead to death
Contra-indications of Bivalirudin
1.Cerebral aneurysm
2.Hypersensitivity to bivalirudin or its components
3.Intracranial hemorrhage
4.General uncontrollable hemorrhage
5.Active major bleeding
Special Precautions while taking Bivalirudin
1.Serious bleeding
2.Hepatic impairment
3.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Bivalirudin
1.Anticoagulation in percutaneous coronary intervention
2.Anticoagulation in patients with unstable angina undergoing percutaneous intervention
3.Heparin-induced thrombocytopenia
Interactions for Bivalirudin
May increase risk of bleeding when used with thrombolytics, oral anticoagulants or drugs that affect platelet function.
Typical Dosage for Bivalirudin
Adult: 750 mcg/kg by IV inj followed by an infusion of 1.75 mg/kg/hr during procedure and up to 4 hr postprocedure. If needed, may continue infusion at 0.2 mg/kg/hr for up to 20 hr.
Schedule of Bivalirudin
Storage Requirements for Bivalirudin
Store unopened vials at 15-30?C. Store reconstituted vials at 2-8?C.
Effects of Missed Dosage of Bivalirudin
Effects of Overdose of Bivalirudin

Home Delivery for Bivalirudin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bivalirudin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bivalirudin and other medicines and health products. Home delivery services for bivalirudin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take bivalirudin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bivalirudin before they complete the sale. You can get this information while placing the order for bivalirudin with the pharmacy.

Bivalirudin is a generic medicine name and there are several brands available for it. Some of the brands for bivalirudin might be better known than bivalirudin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bivalirudin in stock, you can ask for one of the branded alternatives for bivalirudin.