Darifenacin Pharmacology

Darifenacin

About Darifenacin
Antimuscarinic, Antispasmodic
Mechanism of Action of Darifenacin
Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate.
Pharmacokinets of Darifenacin
Absorption: Absorbed after oral administration
Distribution: Distributed in tissue mainly in protein bound (98%) form
Metabolism: Darifenacin undergoes hepatic metabolism
Excretion: Renal (60%) and biliary (40%)
Onset of Action for Darifenacin
Rapid
Duration of Action for Darifenacin
N/A
Half Life of Darifenacin
13 to 19 hours
Side Effects of Darifenacin
1.Constipation
2.Abdominal discomfort
3.Nausea
4.Diarrhea
5.Vomiting
6.Hypertension
7.Headache
8.Dizziness
9.Dry mouth
Contra-indications of Darifenacin
1.Urinary retention
2.Gastric retention
3.Uncontrolled narrow-angle glaucoma
4.Hypersensitivity to any component of the product
Special Precautions while taking Darifenacin
1.Decreased GI motility (such as severe constipation, ulcerative colitis, or myasthenia gravis),
2.Controlled angle-closure glaucoma,
3.Hepatic impairment
4.Pregnant or breastfeeding patients
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Neonates : Contraindicated
Indications for Darifenacin
Overactive bladder with symptoms of urge urinary incontinence, urgency and frequency
Interactions for Darifenacin
1) Interaction of Darifenacin - Anticholinergic agents: Frequency and severity of dry mouth, constipation, blurred vision, and other anticholinergic effects may be increased.
2) Potent CYP3A4 inhibitors (eg, clarithromycin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir): Darifenacin plasma concentrations may be elevated by these agents, increasing the pharmacologic and adverse effects.
Typical Dosage for Darifenacin
Initially, 7.5 mg P.O. daily; may increase to 15 mg P.O. daily as early as 2 weeks after therapy begins
Schedule of Darifenacin
H
Storage Requirements for Darifenacin
Store tablets at controlled room temperature (15-30?C). Protect from light.Keep out of the reach of children.
Effects of Missed Dosage of Darifenacin
N/A
Effects of Overdose of Darifenacin
N/A

Home Delivery for Darifenacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including darifenacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for darifenacin and other medicines and health products. Home delivery services for darifenacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take darifenacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for darifenacin before they complete the sale. You can get this information while placing the order for darifenacin with the pharmacy.

Darifenacin is a generic medicine name and there are several brands available for it. Some of the brands for darifenacin might be better known than darifenacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have darifenacin in stock, you can ask for one of the branded alternatives for darifenacin.