Doxifluridin Pharmacology

Doxifluridin

About Doxifluridin

Antineoplastic,fluropyrimidine derivative.

Mechanism of Action of Doxifluridin

A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Pharmacokinets of Doxifluridin

Absorption: Absorbed rapidly after intravenous administration
Distribution: Widely distributed in the body
Metabolism: metabolised in the liver
Excretion: Excreted throug lung

Onset of Action for Doxifluridin

N/A

Duration of Action for Doxifluridin

N/A

Half Life of Doxifluridin

16.1 to 27.7 min

Side Effects of Doxifluridin

1.Nausea
2.Vomiting
3.Stomatitis
4.Dizziness
5.Ataxia
6.Fatigue
7.Alopecia
8.Loss of appetite
9.Conjunctivitis
10.Fever
11.Chill

Contra-indications of Doxifluridin

N/A

Special Precautions while taking Doxifluridin

1.Cardiac disease
2.Hepatic or Renal insuffiancy

Pregnancy Related Information

N/A

Old Age Related Information

Use with caution

Breast Feeding Related Information

N/A

Children Related Information

Use with caution

Indications for Doxifluridin

1.Colorectal Adenocarcinoma
2.Breast cancer

Interactions for Doxifluridin

Phenytoin reduces the concentration of doxyfluridin

Typical Dosage for Doxifluridin

4000 mg/m2 daily ?5, repeated every 3 weeks. The daily dose was reduced to 3000 mg/m2 in patients who had experienced severe myelosuppression with prior chemotherapy.

Schedule of Doxifluridin

N/A

Storage Requirements for Doxifluridin

Should be stored in impervious break resistant containers.Keep out of the reach of children.

Effects of Missed Dosage of Doxifluridin

N/A

Effects of Overdose of Doxifluridin

N/A

Home Delivery for Doxifluridin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxifluridin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxifluridin and other medicines and health products. Home delivery services for doxifluridin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take doxifluridin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxifluridin before they complete the sale. You can get this information while placing the order for doxifluridin with the pharmacy.

Doxifluridin is a generic medicine name and there are several brands available for it. Some of the brands for doxifluridin might be better known than doxifluridin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxifluridin in stock, you can ask for one of the branded alternatives for doxifluridin.