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- Pharmacology For Memantine + Donepezil
Memantine + Donepezil Pharmacology
Memantine + Donepezil
About Memantine + DonepezilN/AMechanism of Action of Memantine + DonepezilN/APharmacokinets of Memantine + DonepezilN/AOnset of Action for Memantine + DonepezilN/ADuration of Action for Memantine + DonepezilN/AHalf Life of Memantine + DonepezilN/ASide Effects of Memantine + DonepezilN/AContra-indications of Memantine + DonepezilN/ASpecial Precautions while taking Memantine + DonepezilN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Memantine + DonepezilN/AInteractions for Memantine + DonepezilN/ATypical Dosage for Memantine + DonepezilN/ASchedule of Memantine + DonepezilN/AStorage Requirements for Memantine + DonepezilN/AEffects of Missed Dosage of Memantine + DonepezilN/AEffects of Overdose of Memantine + DonepezilN/AMemantine
About MemantineN-Methyl-D-Aspartate Receptor Antagonist, dopamine D2 agonist, Antidementia agent,In Alzheimer`s disease.Mechanism of Action of MemantineMemantine in an uncompetitive (low to moderate affinity to) NMDA (N-methyl-D-aspartate) receptor antagonist. It regulates the activity of glutamate which is involved in information processing, storage and retrieval. Excess glutamate plays a role in neuronal cell death and it is common to all neurodegenerative diseases.
In Alzheimer`s disease excess release of glutamate occurs. Sustained elevation of glutamate over stimulates NMDA receptors and allows too much of calcium in to nerve cells and leads to cell degeneration and cell death. Memantine prevents these actions by inhibiting the binding of glutamate at NMDA receptor.
Pharmacokinets of MemantineAbsorption: Memantine is rapidly absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound and free form. Metabolism: It undergoes partial hepatic metabolism. Excreted: Drug is excreted in urine.Onset of Action for MemantineN/ADuration of Action for MemantineN/AHalf Life of Memantine60 - 80 hoursSide Effects of Memantine1.Dizziness
2.Headache
3.Confusion
4.Constipation
5.Vomiting
6.Fatigue
7.Pain
8.Hypertension
9.Somnolence
10.Hallucination
11.Coughing
12.Dyspepsia
Contra-indications of Memantine1.Hypersensitivity to Memantine.Special Precautions while taking Memantine1.Severe renal impairment
2.People with seizure disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES: contraindicated
Indications for Memantine1. Dementia of Alzheimer`s type.
Interactions for MemantineMedicines that make the urine more alkaline (for example, carbonic anhydrase inhibitors such as acetazolamide (Diamox) and sodium bicarbonate would be expected to reduce the elimination of memantine by the kidneys and might increase the blood levels and the risk of side effects of memantine.Typical Dosage for MemantineAdult: 5 mg once daily; dose can be gradually increased by 5 mg / day every week up to 20 mg / day in 2 divided dosesSchedule of MemantineN/AStorage Requirements for MemantineStore at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of MemantineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MemantineGive supportive measures and symptomatic treatment.Donepezil
About DonepezilCentral Acetylcholinesterase inhibitor, Antidementia agent in Alzheimer`s disease.Mechanism of Action of DonepezilAlzheimer`s disease may result from a deficiency in neurotransmitters used by nerves in the brain to communicate with one another. Donepezil exerts its therapeutic effect by enhancing its cholinergic function. It increases the concentration of Acetylcholine through reversible inhibition of acetyl cholinesterase enzyme which is involved in the hydrolysis of Acetylcholine. It leads to increased concentration of Acetylcholine.This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with donepezil.
Pharmacokinets of DonepezilAbsorption: It is well absorbed after oral administration. Distribution: Donepezil is widely distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Donepezil and its metabolites are excreted mainly in urine and small amount in faeces.Onset of Action for Donepezil2- 4 weeksDuration of Action for DonepezilN/AHalf Life of Donepezil70 hoursSide Effects of Donepezil1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Headache
6.Fatigue
7.Dizziness
8.Insomnia
9.Restlessness
10.Syncope
11.Atrial fibrillation
12.Bradycardia
13.Gastro intestinal haemorrhage
14.Frequent urination
15.Muscle cramps
16.Ulcers
17.Hepatitis
Contra-indications of Donepezil1.Hypersensitivity to DonepezilSpecial Precautions while taking Donepezil1.Cardiovascular diseases
2.Supraventricular cardiac conduction conditions like sick sinus syndrome
3.Asthma
4.Ulcers
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for DonepezilAlzheimer`s disease (To improve memory, awareness, and the ability to function in patients)Interactions for DonepezilAntiarrhythmics: Procainamide, quinidine and probably propafenone antagonise effect of neostigmine & pyridostigmine.
Antibacterials : Aminoglycosides, clindamycin & colistin antagonise effect of neostigmine & pyridostigmine.
Antimuscarinics: Antagonism of effect.
Antimalarials: Chloroquine & hydroxychloroquine have potential to increase symptoms of myasthenia gravis & thus diminish effect of neostigmine & pyridostigmine.
Lithium: antagonism of effect of neostigmine & pyridostigmine.
Muscle relaxants: Possibly donepezil enhances effect of suxamethonium but antagonises effect of non-depolarising muscle relaxants. Typical Dosage for DonepezilAdult: 5 mg / day at bed time if needed after 4 weeks dose can be increased to 10 mg / daySchedule of DonepezilN/AStorage Requirements for DonepezilStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of DonepezilIf you miss a dose skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of DonepezilGive supportive measures and symptomatic treatment. Atropine can be given as antidote.Home Delivery for Memantine + Donepezil in Your City
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Please be aware that you should take memantine + donepezil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for memantine + donepezil before they complete the sale. You can get this information while placing the order for memantine + donepezil with the pharmacy.
Memantine + Donepezil is a generic medicine name and there are several brands available for it. Some of the brands for memantine + donepezil might be better known than memantine + donepezil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have memantine + donepezil in stock, you can ask for one of the branded alternatives for memantine + donepezil.
