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- Pharmacology For Dicyclomine + Dimethyl polysiloxane
Dicyclomine + Dimethyl polysiloxane Pharmacology
Dicyclomine + Dimethyl polysiloxaneAbout Dicyclomine + Dimethyl polysiloxaneN/AMechanism of Action of Dicyclomine + Dimethyl polysiloxaneN/APharmacokinets of Dicyclomine + Dimethyl polysiloxaneN/AOnset of Action for Dicyclomine + Dimethyl polysiloxaneN/ADuration of Action for Dicyclomine + Dimethyl polysiloxaneN/AHalf Life of Dicyclomine + Dimethyl polysiloxaneN/ASide Effects of Dicyclomine + Dimethyl polysiloxaneN/AContra-indications of Dicyclomine + Dimethyl polysiloxaneN/ASpecial Precautions while taking Dicyclomine + Dimethyl polysiloxaneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dicyclomine + Dimethyl polysiloxaneN/AInteractions for Dicyclomine + Dimethyl polysiloxaneN/ATypical Dosage for Dicyclomine + Dimethyl polysiloxaneN/ASchedule of Dicyclomine + Dimethyl polysiloxaneN/AStorage Requirements for Dicyclomine + Dimethyl polysiloxaneN/AEffects of Missed Dosage of Dicyclomine + Dimethyl polysiloxaneN/AEffects of Overdose of Dicyclomine + Dimethyl polysiloxaneN/A
DicyclomineAbout DicyclomineAnticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.Mechanism of Action of DicyclomineDicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.Pharmacokinets of DicyclomineAbsorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine1-2 hours.Duration of Action for Dicyclomine4-6 hours.Half Life of Dicyclomine1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))Side Effects of Dicyclomine1.Constipation
11.Increased intraocular pressure
Contra-indications of Dicyclomine1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
6.Severe ulcerative colitis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine1.Renal impairment
5.Hiatus hernia associated
11.Coronary artery disease
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Dicyclomine1. Irritable bowel syndrome
Interactions for DicyclomineN/ATypical Dosage for DicyclomineAdult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of DicyclomineHStorage Requirements for DicyclomineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of DicyclomineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DicyclomineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.
Dimethyl polysiloxaneAbout Dimethyl polysiloxaneA silicone derivative,Anti-foaming agent, Antiflatulent.Mechanism of Action of Dimethyl polysiloxaneDimethyl polysiloxane is a silicone derivative which is used in symptomatic treatment of postprandial and postoperative flatulence and abdominal distension.It acts as defoaming agent and eliminates gases from GI tract.It is used in combination with antacids,antispasmodics and digestants.Pharmacokinets of Dimethyl polysiloxaneN/AOnset of Action for Dimethyl polysiloxaneN/ADuration of Action for Dimethyl polysiloxaneN/AHalf Life of Dimethyl polysiloxaneN/ASide Effects of Dimethyl polysiloxaneN/AContra-indications of Dimethyl polysiloxaneHypersensitivity to Dimethyl PolysiloxaneSpecial Precautions while taking Dimethyl polysiloxaneKidney failurePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dimethyl polysiloxane1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethyl polysiloxaneN/ATypical Dosage for Dimethyl polysiloxane40 mg tablet to be taken half an hour before food.
Schedule of Dimethyl polysiloxaneN/AStorage Requirements for Dimethyl polysiloxaneStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of Dimethyl polysiloxaneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dimethyl polysiloxaneGive symptomatic and supportive treatment.
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Dicyclomine + Dimethyl polysiloxane is a generic medicine name and there are several brands available for it. Some of the brands for dicyclomine + dimethyl polysiloxane might be better known than dicyclomine + dimethyl polysiloxane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + dimethyl polysiloxane in stock, you can ask for one of the branded alternatives for dicyclomine + dimethyl polysiloxane.