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- Pharmacology For Azithromycin + Benzalkonium Chloride
Azithromycin + Benzalkonium Chloride Pharmacology
Azithromycin + Benzalkonium Chloride
About Azithromycin + Benzalkonium ChlorideN/AMechanism of Action of Azithromycin + Benzalkonium ChlorideN/APharmacokinets of Azithromycin + Benzalkonium ChlorideN/AOnset of Action for Azithromycin + Benzalkonium ChlorideN/ADuration of Action for Azithromycin + Benzalkonium ChlorideN/AHalf Life of Azithromycin + Benzalkonium ChlorideN/ASide Effects of Azithromycin + Benzalkonium ChlorideN/AContra-indications of Azithromycin + Benzalkonium ChlorideN/ASpecial Precautions while taking Azithromycin + Benzalkonium ChlorideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Azithromycin + Benzalkonium ChlorideN/AInteractions for Azithromycin + Benzalkonium ChlorideN/ATypical Dosage for Azithromycin + Benzalkonium ChlorideN/ASchedule of Azithromycin + Benzalkonium ChlorideN/AStorage Requirements for Azithromycin + Benzalkonium ChlorideN/AEffects of Missed Dosage of Azithromycin + Benzalkonium ChlorideN/AEffects of Overdose of Azithromycin + Benzalkonium ChlorideN/AAzithromycin
About AzithromycinAn Azalide, macrolide antibiotic.
Mechanism of Action of AzithromycinAzithromycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Azithromycin is active against both gram positive and gram negative aerobic and anaerobic bacteriaPharmacokinets of AzithromycinAbsorption: Azithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is not metabolized in the body. Excretion: It is primarily excreted through bile and a very small amount excreted through urine.Onset of Action for Azithromycin1-2 hours.Duration of Action for AzithromycinN/AHalf Life of Azithromycin68 hourSide Effects of Azithromycin1. Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Angioedema
6.Rash
7.Urticaria
8.Headache
9.Dizziness
10.Fever
11.Cholestatic jaundice
12.Hearing disturbances
13.Vertigo
Contra-indications of Azithromycin1.Hypersensitivity to Azithromycin and other macrolideSpecial Precautions while taking Azithromycin1.Renal impairment
2.Hepatic dysfunction
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with cautionIndications for Azithromycin1.Pneumonia
2.Tonsilitis
3.Pharyngitis
4.Sinusitis
5.Urethritis
6.Cervicitis
7.SABE
8.Trachoma
9.Prevention of disseminated Mycobacterium avium complex infection
10.Otitis media
11.Chancroid
12..Acne
13.Urogenital infection
14.Skin and soft tissue infections
15.Toxoplasmosis
Interactions for AzithromycinAluminium & Magnesium containing Antacids: Decrease peak serum levels.
Theophylline: Serum concentration of Theophylline increased.
Warfarin: Anticoagulant effects enhanced.
Digoxin & Cyclosporine: Increase in their serum concentration.
Carbamazepine: Toxicity occurs which may require hospitalization.
Triazolam: Increases serum levels of Triazolam leading to toxicity.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Food: Absorption reduced by as much as 52% (should be taken 1 hr before or 2 hrs after meal).
Typical Dosage for AzithromycinAdult:
500 mg once daily for 1 day followed by 250 mg once daily for 4 days.
For the treatment of urethritis and cervicitis: 1 - 2 g as a single dose
Prophylaxis of MAC: 1200 mg once weekly
Chancroid: 1000 mg as a single dose
Children: 10 mg / kg body weight once daily on 1 day followed by 5 mg / kg body weight once daily for 4 days.
Schedule of AzithromycinHStorage Requirements for AzithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of AzithromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of AzithromycinGive supportive measures and symptomatic treatmentBenzalkonium Chloride
About Benzalkonium ChlorideA nitrogenous cationic surfactant, Quaternary ammonium compound, Antiseptic,Disinfectant, A vaginal contraceptive spermicidal agent.Mechanism of Action of Benzalkonium ChlorideThe mechanism of bactericidal/microbicidal action is due to disruption of intermolecular interactions. This cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. It also inactivates the enzyme produced by different microorganisms. It also has spermicidal action. They work by damaging and killing sperm in the vagina. Therefore, the sperm are not able to travel from the vagina into the uterus and fallopian tubes, where fertilization usually takes place.Pharmacokinets of Benzalkonium ChlorideN/AOnset of Action for Benzalkonium ChlorideN/ADuration of Action for Benzalkonium ChlorideN/AHalf Life of Benzalkonium ChlorideN/ASide Effects of Benzalkonium Chloride1. Chills
2. Confusion
3. Dizziness
4. Fever
5. Lightheadedness
6. Muscle aches
7. Sunburn-like skin rash
8. Cloudy or bloody urine
9. Increased frequency of urination
10. Pain in the bladder or lower abdomen
11. Pain on urination; thick
12. White or curd-like vaginal discharge-with use of cervical caps or diaphragms
13. Vaginal dryness
14. Odor
Contra-indications of Benzalkonium Chloride1. Hypersensitivity to the drug
2. Allergies, irritations, or infections of the genitals
3. Recent abortion
4. Sores on the genitals (sex organs)
5. Irritation of the vagina
Special Precautions while taking Benzalkonium ChlorideDiscontinue use if you have abnormal discharge or vaginal burning or itching.Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Benzalkonium Chloride1. Antisepsis of skin, mucous membranes, and wounds.
2. Preoperative preparation of the skin, surgeons` hand and arm soaks
3. Treatment of wounds
4. Preservation of ophthalmic solutions
5. Irrigations of the eye, body cavities, bladder, urethra
6. Vaginal douching.
7. Contraceptives
Interactions for Benzalkonium ChlorideN/ATypical Dosage for Benzalkonium ChlorideVaginal suppositories dosage form (preventing pregnancy):
Adults and teenagers-
For use alone: One suppository inserted into the vagina at least ten minutes but not longer than four hours before each time you have sexual intercourse.
With a diaphragm: After the diaphragm with spermicide has been placed into the vagina, insert one suppository at least ten minutes, but not longer than four hours, before each time you have sexual intercourse. Also, insert another suppository before sexual intercourse if six hours have passed since you inserted the diaphragm
Schedule of Benzalkonium ChlorideN/AStorage Requirements for Benzalkonium ChlorideStore at controlled room temperature, away from light and excessive heat. Keep out of reach of children.Effects of Missed Dosage of Benzalkonium ChlorideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Benzalkonium ChlorideN/AHome Delivery for Azithromycin + Benzalkonium Chloride in Your City
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Azithromycin + Benzalkonium Chloride is a generic medicine name and there are several brands available for it. Some of the brands for azithromycin + benzalkonium chloride might be better known than azithromycin + benzalkonium chloride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have azithromycin + benzalkonium chloride in stock, you can ask for one of the branded alternatives for azithromycin + benzalkonium chloride.
