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- Pharmacology For Abacavir + Zidovudine + Lamivudine
Abacavir + Zidovudine + Lamivudine Pharmacology
Abacavir + Zidovudine + Lamivudine
About Abacavir + Zidovudine + LamivudineN/AMechanism of Action of Abacavir + Zidovudine + LamivudineN/APharmacokinets of Abacavir + Zidovudine + LamivudineN/AOnset of Action for Abacavir + Zidovudine + LamivudineN/ADuration of Action for Abacavir + Zidovudine + LamivudineN/AHalf Life of Abacavir + Zidovudine + LamivudineN/ASide Effects of Abacavir + Zidovudine + LamivudineN/AContra-indications of Abacavir + Zidovudine + LamivudineN/ASpecial Precautions while taking Abacavir + Zidovudine + LamivudineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Abacavir + Zidovudine + LamivudineN/AInteractions for Abacavir + Zidovudine + LamivudineN/ATypical Dosage for Abacavir + Zidovudine + LamivudineN/ASchedule of Abacavir + Zidovudine + LamivudineN/AStorage Requirements for Abacavir + Zidovudine + LamivudineN/AEffects of Missed Dosage of Abacavir + Zidovudine + LamivudineN/AEffects of Overdose of Abacavir + Zidovudine + LamivudineN/AAbacavir
About AbacavirReverse Transcriptase Inhibitor (Nucleoside), Antiretroviral Agent.Mechanism of Action of AbacavirAbacavir is a guanosine nucleoside analogue. It undergoes phosphorylation in the presence of phosphotransferase and Kinase enzyme and form Carbovir triphosphate. This Carbovir triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and it is then added to host cell chromosome Carbovir triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.Pharmacokinets of AbacavirAbsorption: It is rapidly and extensively absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes intracellular metabolism to the active antiviral metabolite Carbovir triphosphate. Excretion: It is excreted mainly in urine.Onset of Action for AbacavirN/ADuration of Action for AbacavirN/AHalf Life of Abacavir60 - 120 minutesSide Effects of Abacavir1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Malaise
6.Fever
7.Pruritis
8.Rash
9.Headache
10.Pharyngitis
11.Cough
Contra-indications of AbacavirHypersensitivity to AbacavirSpecial Precautions while taking Abacavir1.Renal impairment
2.Hepatic impairment (Hepatomegaly, Lactic acidosis)Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be used
NEONATES: ContraindicatedIndications for AbacavirHIV infection in combination with other antiretroviral drugs.Interactions for AbacavirAnalgesics: Plasma concentration of methadone possibly decreased by abacavir.
Typical Dosage for AbacavirAdult: 600 mg / day in 2 divided doses combine with other antiretroviral agents.
Children: 16 mg / kg body weight / day in 2 divided doses
Schedule of AbacavirHStorage Requirements for AbacavirStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of AbacavirTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose.Effects of Overdose of AbacavirGive supportive measures and treatment.Zidovudine
About ZidovudineNucleoside Reverse Transcriptase Inhibitor, thymidine analog, Antiretroviral.Mechanism of Action of ZidovudineZidovudine is a Thymidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Zidovudine triphosphate. This Zidovudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Zidovudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.Pharmacokinets of ZidovudineAbsorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes rapid metabolism in the liver.
Excretion: It is excreted in urine.
Onset of Action for Zidovudine30 - 90 minutesDuration of Action for ZidovudineN/AHalf Life of Zidovudine60 minutesSide Effects of Zidovudine1. Nausea
2. Vomiting
3. Diarrhoea
4. Anorexia
5. Headache
6. Dizziness
7. Anaemia
8. Agranulocytosis
9. Thrombocytopenia
10. Myalgia
11. Rash
Contra-indications of Zidovudine1. Hypersensitivity to ZidovudineSpecial Precautions while taking Zidovudine1. Renal impairment
2. Hepatic dysfunction (Hepatitis, hepatomegaly)
3. Patient with severe bone marrow suppression
4. Pre existing anaemia
5. Granulocytopenia
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be used
NEONATES : Contraindicated
Indications for Zidovudine1. HIV infectionsInteractions for ZidovudineDapsone, Pentamidine, Amphotericin B, Flucytosine, Vincristine, Vinblastine, Adriamycin, Interferon: Concomitant use with drugs that are nephrotoxic, cytotoxic or myelosuppressive may increase toxicity risk.
Trimethoprim:The serum levels of Zidovudine and its metabolite may be increased.
Probenecid:Toxicity of either drug may be potentiated.
Acetaminophen: Increased incidence of granulocytopenia.
Acyclovir: Concomitant use may result in neurotoxicity.
Phenytoin: Altered phenytoin levels. Zidovudine clearance decreased by phenytoin.
Typical Dosage for ZidovudineAdult: 600 mg / day in 2 - 3 divided dose
Asymptomatic HIV infection and for preventing HIV transmission from mother to fetus: 100 mg 5 times daily; should be taken every 4 hours.
Children: 720 mg / sq.metre / day in 4 divided dose in equal interval
Schedule of ZidovudineHStorage Requirements for ZidovudineStore it at 15 -25 degree C in a tightly closed container . Protect away from heat and light. Keep out of the reach of children.Effects of Missed Dosage of ZidovudineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose.Effects of Overdose of ZidovudineGive supportive measures and treatment.Lamivudine
About LamivudineNucleoside Reverse Transcriptase Inhibitor ,cytidine analogue, Antiretroviral.Mechanism of Action of LamivudineLamivudine is a deoxy cytidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Lamivudine triphosphate. This Lamivudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Lamivudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. Lamivudine triphosphate is also a potent inhibitor of HBV (hepatitis B virus)Pharmacokinets of LamivudineAbsorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: Metabolism is insignificant. Excretion: It is excreted in urineOnset of Action for LamivudineN/ADuration of Action for LamivudineN/AHalf Life of Lamivudine5 - 7 hoursSide Effects of Lamivudine1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Headache
6.Dizziness
7.Anaemia
8.Neutropenia
9.Thrombocytopenia
10.Myalgia
11.Rash
12.FeverContra-indications of LamivudineHypersensitivity to LamivudineSpecial Precautions while taking Lamivudine1.Renal impairment
2.Hepatic dysfunctionPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Lamivudine1.HIV infections
2.Treatment of chronic Hepatitis BInteractions for LamivudineTrimethoprim, sulfamethoxazole: Results in an increase in AUC of Lamivudine and a decrease in renal clearance.
Zidovudine: Results in an increase in C max. of Zidovudine.Typical Dosage for LamivudineAdult: 100 - 300 mg / day in 2 divided dose
HIV infection: 300 mg / day in 2 divided dose
Treatment of chronic Hepatitis B: 100 mg / day
Children: 4 - 8 mg / kg /day in 2 divided dose
HIV infection: 4 mg / kg /day in 2 divided dose
Schedule of LamivudineHStorage Requirements for LamivudineStore it at 15 -25 degree C in a tightly closed container .Protect away from heat and lightEffects of Missed Dosage of LamivudineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the doseEffects of Overdose of LamivudineGive supportive measures and treatment.Home Delivery for Abacavir + Zidovudine + Lamivudine in Your City
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Abacavir + Zidovudine + Lamivudine is a generic medicine name and there are several brands available for it. Some of the brands for abacavir + zidovudine + lamivudine might be better known than abacavir + zidovudine + lamivudine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have abacavir + zidovudine + lamivudine in stock, you can ask for one of the branded alternatives for abacavir + zidovudine + lamivudine.
