Abacavir + Lamivudine Pharmacology

Abacavir + Lamivudine

About Abacavir + Lamivudine
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Mechanism of Action of Abacavir + Lamivudine
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Pharmacokinets of Abacavir + Lamivudine
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Onset of Action for Abacavir + Lamivudine
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Duration of Action for Abacavir + Lamivudine
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Half Life of Abacavir + Lamivudine
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Side Effects of Abacavir + Lamivudine
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Contra-indications of Abacavir + Lamivudine
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Special Precautions while taking Abacavir + Lamivudine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Abacavir + Lamivudine
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Interactions for Abacavir + Lamivudine
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Typical Dosage for Abacavir + Lamivudine
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Schedule of Abacavir + Lamivudine
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Storage Requirements for Abacavir + Lamivudine
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Effects of Missed Dosage of Abacavir + Lamivudine
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Effects of Overdose of Abacavir + Lamivudine
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Abacavir

About Abacavir
Reverse Transcriptase Inhibitor (Nucleoside), Antiretroviral Agent.
Mechanism of Action of Abacavir
Abacavir is a guanosine nucleoside analogue. It undergoes phosphorylation in the presence of phosphotransferase and Kinase enzyme and form Carbovir triphosphate. This Carbovir triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and it is then added to host cell chromosome Carbovir triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication.
Pharmacokinets of Abacavir
Absorption: It is rapidly and extensively absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes intracellular metabolism to the active antiviral metabolite Carbovir triphosphate. Excretion: It is excreted mainly in urine.
Onset of Action for Abacavir
N/A
Duration of Action for Abacavir
N/A
Half Life of Abacavir
60 - 120 minutes
Side Effects of Abacavir
1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Malaise
6.Fever
7.Pruritis
8.Rash
9.Headache
10.Pharyngitis
11.Cough
Contra-indications of Abacavir
Hypersensitivity to Abacavir
Special Precautions while taking Abacavir
1.Renal impairment
2.Hepatic impairment (Hepatomegaly, Lactic acidosis)
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
NEONATES: Contraindicated
Indications for Abacavir
HIV infection in combination with other antiretroviral drugs.
Interactions for Abacavir
Analgesics: Plasma concentration of methadone possibly decreased by abacavir.
Typical Dosage for Abacavir
Adult: 600 mg / day in 2 divided doses combine with other antiretroviral agents.
Children: 16 mg / kg body weight / day in 2 divided doses
Schedule of Abacavir
H
Storage Requirements for Abacavir
Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Abacavir
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule. Do not double the dose.
Effects of Overdose of Abacavir
Give supportive measures and treatment.

Lamivudine

About Lamivudine
Nucleoside Reverse Transcriptase Inhibitor ,cytidine analogue, Antiretroviral.
Mechanism of Action of Lamivudine
Lamivudine is a deoxy cytidine nucleoside analogue. It undergoes phosphorylation in the presence of Kinase enzyme and form Lamivudine triphosphate. This Lamivudine triphosphate competitively inhibit HIV reverse transcriptase enzyme which is responsible for the conversion of viral RNA to pro viral DNA and is then added to host cell chromosome. Lamivudine triphosphate terminates elongation of pro viral DNA and results in inhibition of viral replication. Lamivudine triphosphate is also a potent inhibitor of HBV (hepatitis B virus)
Pharmacokinets of Lamivudine
Absorption: It is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: Metabolism is insignificant. Excretion: It is excreted in urine
Onset of Action for Lamivudine
N/A
Duration of Action for Lamivudine
N/A
Half Life of Lamivudine
5 - 7 hours
Side Effects of Lamivudine
1.Nausea
2.Vomiting
3.Diarrhoea
4.Anorexia
5.Headache
6.Dizziness
7.Anaemia
8.Neutropenia
9.Thrombocytopenia
10.Myalgia
11.Rash
12.Fever
Contra-indications of Lamivudine
Hypersensitivity to Lamivudine
Special Precautions while taking Lamivudine
1.Renal impairment
2.Hepatic dysfunction
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Lamivudine
1.HIV infections
2.Treatment of chronic Hepatitis B
Interactions for Lamivudine
Trimethoprim, sulfamethoxazole: Results in an increase in AUC of Lamivudine and a decrease in renal clearance.
Zidovudine: Results in an increase in C max. of Zidovudine.
Typical Dosage for Lamivudine
Adult: 100 - 300 mg / day in 2 divided dose
HIV infection: 300 mg / day in 2 divided dose
Treatment of chronic Hepatitis B: 100 mg / day
Children: 4 - 8 mg / kg /day in 2 divided dose
HIV infection: 4 mg / kg /day in 2 divided dose

Schedule of Lamivudine
H
Storage Requirements for Lamivudine
Store it at 15 -25 degree C in a tightly closed container .Protect away from heat and light
Effects of Missed Dosage of Lamivudine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and do not double the dose
Effects of Overdose of Lamivudine
Give supportive measures and treatment.

Home Delivery for Abacavir + Lamivudine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for abacavir + lamivudine and other medicines and health products. Home delivery services for abacavir + lamivudine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take abacavir + lamivudine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for abacavir + lamivudine before they complete the sale. You can get this information while placing the order for abacavir + lamivudine with the pharmacy.

Abacavir + Lamivudine is a generic medicine name and there are several brands available for it. Some of the brands for abacavir + lamivudine might be better known than abacavir + lamivudine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have abacavir + lamivudine in stock, you can ask for one of the branded alternatives for abacavir + lamivudine.