Febuxostat Pharmacology

Febuxostat

About Febuxostat
Xanthine oxidase inhibitor.For treatment of gout and hyperuricemia
Mechanism of Action of Febuxostat
Mechanism of action: Febuxostat is a non-purine selective inhibitor of xanthine oxidase. It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.
Pharmacokinets of Febuxostat
Absorption: Absorbed after oral administration
Distribution: Bound to protein(albumin)
Metabolism: Metabolised in the liver
Excretion: Excreted through urinr and feces
Onset of Action for Febuxostat
N/A
Duration of Action for Febuxostat
N/A
Half Life of Febuxostat
5 to 8 hrs
Side Effects of Febuxostat
1.Chest pain
2.Nausea
3.Rash
4.Joint pain
5.Gout flares
6.Liver problems
7.Hypersensitivity
8.Weight loss
9.Anemia
Contra-indications of Febuxostat
1.Hypersensitivity to drug
2.Coadministration with azathioprine,mercaptopurine,or theophylline
Special Precautions while taking Febuxostat
1.Kidney disease
2.Liver disease
3.Heart disease
4.High blood pressure
5.Diabetes
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Febuxostat
Chronic management of hyperuricemia in patients with gout.
Interactions for Febuxostat
Febuxostat may increase blood levels of mercaptopurine, azathioprine,theophylline by reducing their breakdown in the body.
Typical Dosage for Febuxostat
Start with 40 mg once daily. The dosage may be increased to 80 mg once daily for patients who do not achieve a serum uric acid less than 6 mg/dL after 14 days.
Schedule of Febuxostat
H
Storage Requirements for Febuxostat
Stored at room temperature between 15 to degree C (59 to 86 degree F).Keep out of the reach of children.
Effects of Missed Dosage of Febuxostat
N/A
Effects of Overdose of Febuxostat
N/A

Home Delivery for Febuxostat in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including febuxostat.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for febuxostat and other medicines and health products. Home delivery services for febuxostat may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take febuxostat only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for febuxostat before they complete the sale. You can get this information while placing the order for febuxostat with the pharmacy.

Febuxostat is a generic medicine name and there are several brands available for it. Some of the brands for febuxostat might be better known than febuxostat itself. If the pharmacy that's willing to deliver medicines to your home doesn't have febuxostat in stock, you can ask for one of the branded alternatives for febuxostat.