Aliskiren Pharmacology


About Aliskiren
Antihypertensive, Non peptide renin inhibitor
Mechanism of Action of Aliskiren
Aliskiren inhibiting the enzyme renin, it prevents conversion of angiotensinogen into angiotensin I and therefore inhibits subsequent production of angiotensin II and aldosterone. Unlike ACE inhibitors and angiotensin II receptor antagonists which cause a compensatory rise in plasma renin activity, treatment with aliskiren decreases plasma renin activity and concentrations of angiotensin I, angiotensin II and aldosterone.
Pharmacokinets of Aliskiren
Onset of Action for Aliskiren
Duration of Action for Aliskiren
Long duration of action
Half Life of Aliskiren
24 hrs
Side Effects of Aliskiren
5.Gastro-oesophageal reflux
Contra-indications of Aliskiren
Special Precautions while taking Aliskiren
1.Renal impairment
2.Heart problem
3.Severe Diarrhoea
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Aliskiren
Interactions for Aliskiren
Irbesartan: Decreased aliskiren concentrations
Atorvastatin and Ketoconazole: Increased aliskiren concentration
Furosemide: Decreased furosemide concentration
Potassium-sparing diuretics, Potassium supplements: Increased risk of hyperkalaemia
Typical Dosage for Aliskiren
Adult: ?18 yr: 150 mg once daily, increased to 300 mg once daily if needed
Schedule of Aliskiren
Storage Requirements for Aliskiren
Store between 15-30?C (59-86?F)in well closed container. Protect from moisture. Keep out of the reach of children.
Effects of Missed Dosage of Aliskiren
Effects of Overdose of Aliskiren

Home Delivery for Aliskiren in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aliskiren.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aliskiren and other medicines and health products. Home delivery services for aliskiren may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aliskiren only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aliskiren before they complete the sale. You can get this information while placing the order for aliskiren with the pharmacy.

Aliskiren is a generic medicine name and there are several brands available for it. Some of the brands for aliskiren might be better known than aliskiren itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aliskiren in stock, you can ask for one of the branded alternatives for aliskiren.