Benzathine Penicillin Pharmacology

Benzathine Penicillin

About Benzathine Penicillin
Penicillin derivarive antibiotic, Systemic
Mechanism of Action of Benzathine Penicillin
It is a bactericidal drug.It is a beta lactam antibiotic.It binds to the penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis.It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis.Penicillin is more active against gram positive organism than gram negative organism.
Pharmacokinets of Benzathine Penicillin
Absorption: Absorbed after IM injection
Distribution: Protein binding is 50 to 65%
Excretion: Excreted through urine
Onset of Action for Benzathine Penicillin
12 to 24 hrs
Duration of Action for Benzathine Penicillin
Prolonged duration of action
Half Life of Benzathine Penicillin
0.5 to 1 hr
Side Effects of Benzathine Penicillin
Anaphylactoid reactions
Allergic reactions
Loose stools
Burning discomfort
Local pain
Contra-indications of Benzathine Penicillin
Special Precautions while taking Benzathine Penicillin
Kidney disease
Stomach or intestine disease
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Benzathine Penicillin
Acute otitis media
Bacterial infections
Diphtheria carriers
Penicillin sensitive infections
Prophylaxis of rheumatic fever
Streptococal impetigo
Interactions for Benzathine Penicillin
Probenecid: Decreases the renal clearance
Allergies to penicillins or other antibiotics
Typical Dosage for Benzathine Penicillin
Adult: 0.600 to 1.200 million units: Single dose every 3 weeks dose and duration may vary according to indication
Neonatal dosage: 28.625 mg/kg 8 hourly
Schedule of Benzathine Penicillin
Storage Requirements for Benzathine Penicillin
Store in a well closed container,below 30 degree celcius.Keep out of the reach of children
Effects of Missed Dosage of Benzathine Penicillin
Effects of Overdose of Benzathine Penicillin

Home Delivery for Benzathine Penicillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including benzathine penicillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for benzathine penicillin and other medicines and health products. Home delivery services for benzathine penicillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take benzathine penicillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for benzathine penicillin before they complete the sale. You can get this information while placing the order for benzathine penicillin with the pharmacy.

Benzathine Penicillin is a generic medicine name and there are several brands available for it. Some of the brands for benzathine penicillin might be better known than benzathine penicillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have benzathine penicillin in stock, you can ask for one of the branded alternatives for benzathine penicillin.