Benztropine Pharmacology

Benztropine

About Benztropine
Anticholinergic(Antimuscarinic),Antihistaminic
Mechanism of Action of Benztropine
Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement
Pharmacokinets of Benztropine
Absorption: Absorbed after oral, IM, IV
Distribution: Protein binding about 95%; crosses blood brain barrier
Metabolism: Hepatic metabolism by N-oxidation, N-dealkylation, and ring hydroxylation
Onset of Action for Benztropine
Within 1 hr (oral); within 15 min (parenteral)
Duration of Action for Benztropine
6-48 hr
Half Life of Benztropine
N/A
Side Effects of Benztropine
1.Nausea
2.Vomiting
3.Dry mouth
4.Allergic reaction constipation
5.Toxic psychosis
6.Numbness of fingers
7.Blurred vision
Contra-indications of Benztropine
1.Prostatic hypertrophy
2.Myasthenia gravis
Special Precautions while taking Benztropine
1.Heart problem
2.Liver problem
3.Kidney problem
4.GI disease
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
<3 yrs: Contraindicated
Indications for Benztropine
1.Ideopathic parkinsonism
2.Postencephalitic parkinsonism
3.Acute dystonic reactions
Interactions for Benztropine
Concomitant use of drugs with anticholinergic activity may enhance the actions or side effects of anticholinergic drugs
Acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine): May diminish the activity of acetylcholinesterase
Levodopa: Reduces absorption of levodopa
Typical Dosage for Benztropine
Initial: 0.5 to 2 mg administered orally, IM, or IV, once a day.
Idiopathic parkinsonism: Start with a dose of 0.5 to 1 mg orally once daily at bedtime.
Postencephalitic parkinsonism: Most patients require larger doses. It may be appropriate to initiate therapy at 1 to 2 mg orally once daily at bedtime.
Maintenance: Titration up from the initial dose should occur gradually by raising the dose in 0.5 mg increments every 5 to 6 days, up to 6 mg/day, until optimal relief is obtained
Acute dystonia
Adult: 1-2 mg by IM/IV; no significant difference on onset of effect. May be followed by 1-2 mg bid orally to prevent recurrence
Schedule of Benztropine
N/A
Storage Requirements for Benztropine
Store Below 40?C. Protect from Sunlight and Moisture.Keep out of the reach of children
Effects of Missed Dosage of Benztropine
N/A
Effects of Overdose of Benztropine
N/A

Home Delivery for Benztropine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including benztropine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for benztropine and other medicines and health products. Home delivery services for benztropine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take benztropine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for benztropine before they complete the sale. You can get this information while placing the order for benztropine with the pharmacy.

Benztropine is a generic medicine name and there are several brands available for it. Some of the brands for benztropine might be better known than benztropine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have benztropine in stock, you can ask for one of the branded alternatives for benztropine.