Brompheniramine Maleate + Pseudoephedrine Pharmacology

Brompheniramine Maleate + Pseudoephedrine

About Brompheniramine Maleate + Pseudoephedrine
N/A
Mechanism of Action of Brompheniramine Maleate + Pseudoephedrine
Brompheniramine maleate is an antihistamine with H1-receptor activity; pseudoephedrine, a sympathomimetic amine and isomer of ephedrine, acts as a decongestant in respiratory tract mucous membranes with less vasoconstrictor action than ephedrine in normotensive individuals
Pharmacokinets of Brompheniramine Maleate + Pseudoephedrine
N/A
Onset of Action for Brompheniramine Maleate + Pseudoephedrine
N/A
Duration of Action for Brompheniramine Maleate + Pseudoephedrine
N/A
Half Life of Brompheniramine Maleate + Pseudoephedrine
N/A
Side Effects of Brompheniramine Maleate + Pseudoephedrine
N/A
Contra-indications of Brompheniramine Maleate + Pseudoephedrine
1.Stroke
2.Palpitations
3.Insomnia
Special Precautions while taking Brompheniramine Maleate + Pseudoephedrine
1.Impaired hepatic or renal function
2.Prostatic hypertrophy
3.Hyperthyroidism
4.Glaucoma
5.Cardiac disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Brompheniramine Maleate + Pseudoephedrine
1.Allergic rhinitis
2.Nasal congestion
3.Vasomotor rhinitis
Interactions for Brompheniramine Maleate + Pseudoephedrine
N/A
Typical Dosage for Brompheniramine Maleate + Pseudoephedrine
Capsule, long acting:
Children 6-12 years: 1 capsule every 12 hours
Adults and children> 12 yrs: 1-2 capsules every 12 hours
Syrrup
Adult & childn >12 yr 5 mL: 3 times daily
Childn 6-12 yr: 2.5 mL 3 times daily
2-5 yr: 1.25 mL 3 times daily
Schedule of Brompheniramine Maleate + Pseudoephedrine
N/A
Storage Requirements for Brompheniramine Maleate + Pseudoephedrine
Stored in a tightly closed container.Keep out of the reach of children
Effects of Missed Dosage of Brompheniramine Maleate + Pseudoephedrine
N/A
Effects of Overdose of Brompheniramine Maleate + Pseudoephedrine
N/A

Brompheniramine Maleate

About Brompheniramine Maleate
Antihistamins,Alkylamine derivative
Mechanism of Action of Brompheniramine Maleate
This has peripheral H1 receptor antagonist action and compete with histamine for binding to the receptor present on bronchi,uterus etc.This inhibits the activation of receptor and corresponding allergic symptoms produced by it.Centrally the drug also has some antimuscarinic activity
Pharmacokinets of Brompheniramine Maleate
Absorption: Absorbed after oral administration
Distribution: Widely distributed
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for Brompheniramine Maleate
N/A
Duration of Action for Brompheniramine Maleate
4 to 25 hrs
Half Life of Brompheniramine Maleate
25 hrs
Side Effects of Brompheniramine Maleate
1.Sedation
2.Dryness of mouth
3.Dizziness
4.Disturbed coordination
5.Tremor
6.Irritability
7.Insomnia
8.Visual disturbances
9.Nausea
Contra-indications of Brompheniramine Maleate
1.Hypersensitivity
2.Porphyria
3.Narrow-angle glaucoma
4.Urinary retention
5.Peptic ulcer
6.Asthma
Special Precautions while taking Brompheniramine Maleate
1.Heart disease
2.Liver problem
3.Narrow-angle glaucoma
4.Respiratory impairment
5.Bronchial asthma
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Neonates: Contraindicated
Indications for Brompheniramine Maleate
1.Allergic conjunctivitis
2.Allergic rhinitis
3.Dermatitis
4.NSAID associated ulceration
5.Urticaria
Interactions for Brompheniramine Maleate
Alcohol and other CNS depressants:Addictive effect
MAOIs:Prolong anticholinergic effect
Anticholinergics(some)&Tricyclic Antidepressants:May have enhanced effect
Typical Dosage for Brompheniramine Maleate
Oral
Allergic Conditions
Adult: 4-8 mg 3-4 times daily. Individualise dosage according to patient's response and tolerance.
Child: ?3 yr: 0.4-1 mg/kg/ day, given as 4 divided doses. 3-6 yr: 1-2 mg and 6-12 yr: 2-4 mg, doses to be given 3-4 times daily.
Parenteral
Allergic conditions
Adult: 10 mg every 8-12 hr. Dose can be given via SC, IM or slow IV inj. Max: 40 mg/24 hr.
Schedule of Brompheniramine Maleate
N/A
Storage Requirements for Brompheniramine Maleate
Store Below 40?C. Do not Freeze. Protect from Sunlight and Moisture.Keep out of the reach of children
Effects of Missed Dosage of Brompheniramine Maleate
N/A
Effects of Overdose of Brompheniramine Maleate
N/A

Pseudoephedrine

About Pseudoephedrine
Alpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.
Mechanism of Action of Pseudoephedrine
It is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.
Pharmacokinets of Pseudoephedrine
Absorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.
Onset of Action for Pseudoephedrine
30 minutes
Duration of Action for Pseudoephedrine
4 to 8 hours
Half Life of Pseudoephedrine
N/A
Side Effects of Pseudoephedrine
1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine
1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 years
Special Precautions while taking Pseudoephedrine
1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Pseudoephedrine
1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infections
Interactions for Pseudoephedrine
N/A
Typical Dosage for Pseudoephedrine
Oral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.

Schedule of Pseudoephedrine
N/A
Storage Requirements for Pseudoephedrine
Store at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of children
Effects of Missed Dosage of Pseudoephedrine
Take the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of Pseudoephedrine
Continue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.

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