Cilazapril Pharmacology


About Cilazapril
ACE Inhibitors,Antihypertensives
Mechanism of Action of Cilazapril
Cilazapril is the prodrug of cilazaprilat which is the active metabolite. It causes vasodilation and reduces peripheral resistance. It also inhibits the action of angiotensin-converting enzyme, thus preventing the conversion of angiotensin I to angiotensin II. It may also reduce degradation of bradykinin and affect enzymes involved in the generation of prostaglandins. Reduces both preload and afterload, and left ventricular remodeling.
Pharmacokinets of Cilazapril
Absorption: Absorbed after oral administration
Distribution: Widely distributed to the body
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for Cilazapril
1 hr
Duration of Action for Cilazapril
24 hr
Half Life of Cilazapril
1 to 1.5 hr
Side Effects of Cilazapril
4.GI disturbance
5.Persistent dry cough and other upper resp tract symptoms
6.Renal impairment
7.Blood disorders
8.Skin rashes
Contra-indications of Cilazapril
1.Aortic stenosis or outflow tract obstruction
2.Renovascular disease
Special Precautions while taking Cilazapril
1.Renal impairment
2.Heart failure
3.Sodium depletion should be corrected before starting therapy
4.Use cautiously along with drug that affect WBC counts or immune response.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Cilazapril
2.Heart failure
Interactions for Cilazapril
Potassium-sparing diuretics, K supplements: Additive hyperkalaemic effects
NSAIDs: Diminished antihypertensive effects
Diuretics, other Antihypertensives, Alcohol: Excessive hypotension
Typical Dosage for Cilazapril
Hypertension: Initial: 1 mg once daily. Maintenance: 2.5-5 mg/day
Heart failure: Initial: 0.5 mg once daily. Maintenance: 1-2.5 mg once daily. Max: 5mg/day
Schedule of Cilazapril
Storage Requirements for Cilazapril
Store in a well closed container below 25 degree C.Keep out of the reach of children
Effects of Missed Dosage of Cilazapril
Effects of Overdose of Cilazapril

Home Delivery for Cilazapril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cilazapril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cilazapril and other medicines and health products. Home delivery services for cilazapril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cilazapril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cilazapril before they complete the sale. You can get this information while placing the order for cilazapril with the pharmacy.

Cilazapril is a generic medicine name and there are several brands available for it. Some of the brands for cilazapril might be better known than cilazapril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cilazapril in stock, you can ask for one of the branded alternatives for cilazapril.