Dabigatran Pharmacology


About Dabigatran
Anticoagulant, Direct thrombin inhibitor
Mechanism of Action of Dabigatran
Dabigatran is a reversible direct thrombin inhibitor.Thrombin (factor IIa) is a plasma enzyme that catalyses the conversion of fibrinogen to fibrin, which is central to coagulation.
Pharmacokinets of Dabigatran
Absorption: Absorbed after oral administration
Distribution: Widely distributed in the protein bound form
Metabolism: Metabolised in the liver
Excretion: Excretion mostly through urine, small amount excreted through feces
Onset of Action for Dabigatran
0.5 to 2 hrs
Duration of Action for Dabigatran
Half Life of Dabigatran
14 to 17 hrs
Side Effects of Dabigatran
1.Stomach pain
Contra-indications of Dabigatran
1.Hypersensitivity to the drug
2.Renal impairment
Special Precautions while taking Dabigatran
1.Kidney disease
2.Stomach ulcer or bleeding
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Dabigatran
1.Venous thromboembolic events
2.Prevention of stroke in patients with non-valvular atrial fibrillation
Interactions for Dabigatran
Abciximab: Increase risk of bleeding
NSAID: May increase risk of bleeding
Verapamil: May increase the effect of dabigatran
Typical Dosage for Dabigatran
Patient with normal kidney function: Dose should be 150 mg twice daily
Patient with poor kidney function: Dose should be 75 mg twice daily
Schedule of Dabigatran
Storage Requirements for Dabigatran
Stored in a well closed container and away from excess heat and moisture.Keep out of the reach of children
Effects of Missed Dosage of Dabigatran
Effects of Overdose of Dabigatran

Home Delivery for Dabigatran in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dabigatran.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dabigatran and other medicines and health products. Home delivery services for dabigatran may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dabigatran only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dabigatran before they complete the sale. You can get this information while placing the order for dabigatran with the pharmacy.

Dabigatran is a generic medicine name and there are several brands available for it. Some of the brands for dabigatran might be better known than dabigatran itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dabigatran in stock, you can ask for one of the branded alternatives for dabigatran.